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AB141199

Amphotericin B (AmB), Antimycotic polyene

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MW 924.1 Da, Purity >90%. Antimycotic polyene. Disrupts fungal cell membrane permeability by targeting sterols such as ergosterol. Active in vivo.

대체 명칭 보기

APC1 protein, BAR, Bile acid receptor, Cachectin, DIF, Differentiation inducing factor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, HRR 1, Macrophage cytotoxic factor, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 3 group C member 1, RIP 14, RXR-interacting protein 14, Retinoid X receptor-interacting protein 14, TNF superfamily member 2, TNF, macrophage derived, TNF, monocyte derived, TNF-alpha, TNFA_HUMAN, TNFSF2, Tnf, Tumor Necrosis Factor, Membrane Form, Tumor necrosis factor, Tumor necrosis factor (TNF superfamily member 2), Tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, Tumor necrosis factor, soluble form, erythroid derived 2, glucocorticoid nuclear receptor variant 1, like 2, nr3c1, nuclear factor erythroid 2 like 2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

1 이미지
Chemical Structure - Amphotericin B (AmB), Antimycotic polyene (AB141199)
  • Chemical Structure

Lab

Chemical Structure - Amphotericin B (AmB), Antimycotic polyene (AB141199)

2D chemical structure image of ab141199, Amphotericin B (AmB), Antimycotic polyene

주요 정보

CAS 번호

1397-89-3

Purity

>90%

제형

Solid

form

Molecular weight

924.1 Da

Molecular formula

C<sub>4</sub><sub>7</sub>H<sub>7</sub><sub>3</sub>NO<sub>1</sub><sub>7</sub>

PubChem

5280965

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

생화학적 명칭

Amphotericin B

생물학적 정보

Antimycotic polyene. Disrupts fungal cell membrane permeability by targeting sterols such as ergosterol. Active in vivo.

Canonical SMILES

CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

Isomeric SMILES

C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O

InChi

InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChiKey

APKFDSVGJQXUKY-INPOYWNPSA-N

IUPAC Name

(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

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보완 제품

Assay Kits

AB228554

Cell Counting Kit 8 (WST-8 / CCK8)

Functional Studies - Cell Counting Kit 8 (WST-8 / CCK8) (AB228554)

  • 5
  • 4
Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

  • 5
  • 14
Assay Kits

AB189576

Human Apolipoprotein AI ELISA Kit

SimpleStep

ELISA - Human Apolipoprotein AI ELISA Kit (AB189576)

  • 0
  • 0
Biochemicals

AB144518

Sinefungin, methyltransferase inhibitor

  • 0
  • 0
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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제품 프로토콜

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Product promise

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