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AB141200

Ampicillin trihydrate, beta-lactam antibiotic

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MW 349.4 Da, Purity >98%. β-lactam antibiotic (MIC50 = 3.12 μg/ml). Competitively inhibits transpeptidase causing cell wall disruption to Gram-positive and Gram-negative bacteria. Active in vitro and in vivo.

대체 명칭 보기

DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DinB homolog 1 (E. coli), Eta 2, FLJ16395, FLJ21978, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, XP V, Xeroderma pigmentosum variant type protein, polymerase DNA directed eta, polymerase, DNA, kappa

1 이미지
Chemical Structure - Ampicillin trihydrate, beta-lactam antibiotic (AB141200)
  • Chemical Structure

Lab

Chemical Structure - Ampicillin trihydrate, beta-lactam antibiotic (AB141200)

2D chemical structure image of ab141200, Ampicillin trihydrate, beta-lactam antibiotic

주요 정보

CAS 번호

69-53-4

Purity

>98%

제형

Solid

form

Source

Zea sp.

Molecular weight

349.4 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>9</sub>N<sub>3</sub>O<sub>4</sub>S

PubChem

6249

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 10 mM

생화학적 명칭

Ampicillin

생물학적 정보

β-lactam antibiotic (MIC50 = 3.12 μg/ml). Competitively inhibits transpeptidase causing cell wall disruption to Gram-positive and Gram-negative bacteria. Active in vitro and in vivo.

Canonical SMILES

CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C

Isomeric SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)C

InChi

InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1

InChiKey

AVKUERGKIZMTKX-NJBDSQKTSA-N

IUPAC Name

(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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보완 제품

Primary Antibodies

AB177178

Anti-Histone H3 (acetyl K27) antibody [EP16602] - ChIP Grade

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

ChIP-sequencing - Anti-Histone H3 (acetyl K27) antibody [EP16602] - ChIP Grade (AB177178)

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Reagents, Controls & Accessories

AB146567

Ampicillin sodium (aqueous), beta-lactam antibiotic

Chemical Structure - Ampicillin sodium (aqueous), beta-lactam antibiotic (AB146567)

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Biochemicals

AB217298

ABT-199 (Venetoclax), Bcl-2 inhibitor.

Chemical Structure - ABT-199 (Venetoclax), Bcl-2 inhibitor. (AB217298)

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Biochemicals

AB120129

Y-27632 dihydrochloride, Rho kinase inhibitor

Functional Studies - Y-27632 dihydrochloride, Rho kinase inhibitor (AB120129)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DNA Polymerase iota (Pol ι) DNA Polymerase kappa (POLK) and DNA Polymerase eta (Pol η) are specialized Y-family DNA polymerases. These enzymes play roles in DNA translesion synthesis allowing DNA replication across damaged templates. DNA Polymerase eta for instance may weigh around 80 kDa. These enzymes are expressed in a variety of tissues with higher activity in proliferative cells. Their expression and activity may vary depending on the cell cycle and specific cellular needs for DNA repair.
Biological function summary

These DNA polymerases provide a mechanism for replicative bypass of DNA lesions ensuring continuity of DNA replication. They do not work in isolation but cooperate within the DNA damage tolerance pathways. Pol η part of the error-free damage bypass pathway helps transcribe across UV-induced cyclobutane pyrimidine dimers. Pol ι and POLK participate in mutagenic bypass potentially incorporating incorrect bases opposite certain types of lesions affecting genomic stability to different extents depending on the existing lesion.

Pathways

Pol ι POLK and Pol η play essential roles in the DNA damage response and repair pathways alongside proteins like PCNA (Proliferating Cell Nuclear Antigen) and RPA (Replication Protein A). They take part in pathways such as the post-replication repair (PRR) and nucleotide excision repair (NER) pathways. Through these pathways they interact with other polymerases and accessory proteins to carry on DNA replication functions despite the presence of DNA damage.

Defects or deficiencies in DNA Polymerase eta are connected to xeroderma pigmentosum variant (XP-V) a condition causing extreme sensitivity to UV rays and heightened cancer risk. Mutations in POLK may associate with increased genomic instability contributing to cancers due to error-prone replication past DNA lesions. These polymerases interact with tumor suppressor proteins like p53 and BRCA1 in the context of the cellular response to DNA damage influencing carcinogenesis and cancer progression.
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제품 프로토콜

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Product promise

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