MW 219.24 Da, Purity >99%. Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidpressant and anxiolytic in vivo. Also available in Kit: Ionotropic agonists (ab120323).
대체 명칭 보기
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, AMPA 1, AMPA-selective glutamate receptor 1, CP2C9_HUMAN, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, MGC149605, MGC88320, Microsomal monooxygenase, OTTHUMP00000020135, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, P450 MP, P450 PB 1, P450C2C, P450IIC19, P450IIC9, S-mephenytoin 4-hydroxylase, Xenobiotic monooxygenase, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase
- Chemical Structure
Lab
Chemical Structure - Aniracetam, AMPA receptor poteniator (AB120316)
2D chemical structure image of ab120316, Aniracetam, AMPA receptor poteniator
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취급 방법
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GRIA1 influences cellular signaling through synaptic strength modulation and neuroplasticity important for learning and memory. It forms a part of the larger AMPA receptor complex which includes other subunits like Glutamate Receptor 2 (GRIA2). AMPA receptors' activity may modulate neuronal circuit function and interacts functionally with NMDA receptors to allow calcium permeability upon synaptic excitation. The dynamic expression and function of GRIA1 contribute to maintaining synaptic homeostasis and adaptability.
Pathways
GRIA1 is active in the glutamatergic synapse pathway and plays a significant role in long-term potentiation (LTP) an essential mechanism underlying learning and memory. The receptor’s function connects with NMDA receptors and other signaling proteins such as CaMKII which further propagate intracellular signaling cascades. GRIA1's involvement in these pathways highlights its coordination with other proteins to promote proper synaptic function and neural plasticity.
Product promise
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