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AB141849

APETx2, ASIC3 channel blocker

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(1 출판물)

MW 4561.05 g/mol, Purity >98%. Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.
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Functional Studies - APETx2, ASIC3 channel blocker (AB141849)
  • FuncS

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Functional Studies - APETx2, ASIC3 channel blocker (AB141849)

APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.

Chemical Structure - APETx2, ASIC3 channel blocker (AB141849)
  • Chemical Structure

Lab

Chemical Structure - APETx2, ASIC3 channel blocker (AB141849)

2D chemical structure image of ab141849, APETx2, ASIC3 channel blocker

주요 정보

CAS 번호

713544-47-9

Purity

>98%

제형

Solid

form

Source

Anthopleura elegantissima

Molecular weight

4561.05 g/mol

Nature

Native

Solubility

Soluble in water to 1 mg/ml

생물학적 정보

Selective, reversible ASIC3 channel blocker (IC50 = 63 nM). Inhibits heteromeric ASIC2b and ASIC3 currents (IC50 = 117 nM) and NaV1.8 channels (IC50 = 2.6 μM). Shows analgesic effects in vivo.

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보완 제품

Primary Antibodies

AB259990

Anti-YTHDC1 antibody [EPR21821-213]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-YTHDC1 antibody [EPR21821-213] (AB259990)

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Primary Antibodies

AB237751

Anti-ATG4D antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATG4D antibody (AB237751)

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Biochemicals

AB144534

Chaetocin, histone lysine methyltransferase inhibitor

Chemical Structure - Chaetocin, histone lysine methyltransferase inhibitor (AB144534)

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Sample Prep & Detection Kits

AB102784

Antibody Purification Kit (Protein A)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of nanobiotechnology 22:556 PubMed39267105

2024

A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jun Yu,Yuan-Ting Zhao,Haimiti Abudouaini,Peng Zou,Tian-Qi Li,Xiao-Fan Bai,Shan-Xi Wang,Jian-Bin Guan,Meng-Wei Li,Xiao-Dong Wang,Ying-Guang Wang,Ding-Jun Hao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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