MW 625.6 Da. Dopamine pan-receptor agonist. Displays anti-Parkinson's activity in vivo. Protects against MPTP-induced neurotoxicity (mouse model).
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ACEE, ACES_HUMAN, ACLS, AHR_HUMAN, AIS, ANDR_HUMAN, AR, AR8, ARACHE, ARO, ARO1, Acetylcholinesterase, Ah receptor, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Apoptosis related acetylcholinesterase, Aromatase, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Atherosclerosis, susceptibility to, included, BAR, Bile acid receptor, CAR, CAR BETA, CARA, CHNG1, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Car 1, Class E basic helix-loop-helix protein 76, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESR2_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, FAAR, FXR, Farnesoid X receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HDL cholesterol, augmented response of, to hormone replacement, included, HGNC:348, HRR 1, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), LGR 3, MB67, MGC104309, MGC129539, MGC3931, MGC75129, MGC97144, Microsomal monooxygenase, Myocardial infarction, susceptibility to, included, N-ACHE, NF-E2-related factor 2, NF2L2_HUMAN, NR1B1, NR1C2, NR1C3, NR1F3, NR1H4_HUMAN, NR1I3_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, NRF2, NUC1, NUCI, NUCII, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear hormone receptor 1, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group C member 2, Nuclear receptor subfamily 1 group C member 3, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group H member 4, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000162543, OTTHUMP00000198350, Oncogene GLI3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, P 450AROM, PAP A, PAPB, PPAR-beta, PPAR-delta, PPAR-gamma, PPAR-鑴, PPARB, PPARD_HUMAN, PPARG2, PPARG_HUMAN, PPD IV, Peroxisome proliferative activated receptor delta, Peroxisome proliferator activated receptor gamma 2, Peroxisome proliferator-activated receptor beta, Peroxisome proliferator-activated receptor beta (PPAR-beta), Peroxisome proliferator-activated receptor delta, Peroxisome proliferator-activated receptor gamma, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-related orphan receptor C, RARA_HUMAN, RARalpha1, RIP 14, RNESTROR, RORG_HUMAN, RXR-interacting protein 14, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoid X receptor-interacting protein 14, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, Seven transmembrane helix receptor, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, TOR, TSH Receptor, TSHR_HUMAN, Testicular Feminization (TFM), Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, Transcriptional activator GLI3, Transcriptional repressor GLI3R, YT, YT blood group, Zinc finger protein GLI 3, androgen receptor splice variant 4b, bHLHe76, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, erythroid derived 2, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, hTSHR I, like 2, nuclear factor erythroid 2 like 2, orphan nuclear hormone receptor
- Chemical Structure
Lab
Chemical Structure - Apomorphine HCl, dopamine agonist (AB269887)
Chemical structure of Apomorphine HCl, dopamine agonist, 41372-20-7
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins operate within distinct cellular processes yet can interact in shared pathways. ER alpha and beta form dimers influencing gene expression in response to estrogen. AR similarly translocates to the nucleus after activating by testosterone. In immune response and metabolism Nrf2 partners with Keap1 to manage oxidative stress response. AhR forming a complex with the AhR Nuclear Translocator (ARNT) regulates xenobiotic-metabolizing enzymes. Aromatase located mainly in the gonads and brain critically balances sex steroid levels. Acetylcholinesterase while not part of a complex is indispensable for neuromuscular transmission.
Pathways
All these targets serve prominent roles in interconnected biochemical routes. ER and AR are integral in the estrogen and androgen pathways mediating diverse physiological responses. PPAR gamma and delta are central actors in lipogenesis and fatty acid oxidation influencing metabolic syndrome pathways. ROR gamma interacts with the circadian rhythm pathway and metabolic balance. CAR and AhR modulate the xenobiotic degradation pathway coordinating a response to foreign chemicals. The Hedgehog pathway closely links with Gli3 directing developmental processes. Nrf2 involves the antioxidative stress pathway interacting with proteins like Keap1 to safeguard cells against oxidative damage.
제품이 사용된 논문 (1)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Neuron 112:1150-1164.e6 PubMed38295792
2024
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