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AB145709

Camostat mesylate, TMPRSS2 inhibitor

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(1 출판물)

MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

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1 이미지
Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (AB145709)
  • Chemical Structure

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Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (AB145709)

2D chemical structure image of ab145709, Camostat mesylate, TMPRSS2 inhibitor

주요 정보

CAS 번호

59721-29-8

Purity

>98%

제형

Solid

form

Molecular weight

494.52 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>N<sub>4</sub>O<sub>5</sub>.CH<sub>4</sub>O<sub>3</sub>S

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

생물학적 정보

Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

IUPAC Name

[4-[2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate methanesulfonate

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보완 제품

Primary Antibodies

AB133285

Anti-AVEN antibody [EPR4720]

BOND RX™ Validated|RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-AVEN antibody [EPR4720] (AB133285)

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  • 1
Primary Antibodies

AB79935

Anti-Myosin Light Chain 2 antibody

BOND RX™ Validated

Western blot - Anti-Myosin Light Chain 2 antibody (AB79935)

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  • 2
Biochemicals

AB141382

Z-IETD-FMK, Caspase-8 inhibitor

Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)

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  • 0
Primary Antibodies

AB209813

Anti-Cardiac Troponin T antibody [EPR20266]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Cardiac Troponin T antibody [EPR20266] (AB209813)

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  • 2
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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제품 프로토콜

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nutrients 14: PubMed36014919

2022

Lipid Raft Integrity and Cellular Cholesterol Homeostasis Are Critical for SARS-CoV-2 Entry into Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed Bakillah,Fatimah Al Hejji,Abdulrahman Almasaud,Haya Al Jami,Abbas Hawwari,Ali Al Qarni,Jahangir Iqbal,Naif Khalaf Alharbi
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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