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AB120330

CGP 52432, GABAB antagonist

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(11 제품이 사용된 논문 )

MW 384.2 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 85 nM). Soluble in 1 ml water to give specified mM/ml concentration.
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Chemical Structure - CGP 52432, GABAB antagonist (AB120330)
  • Chemical Structure

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Chemical Structure - CGP 52432, GABAB antagonist (AB120330)

2D chemical structure image of ab120330, CGP 52432, GABAB antagonist

주요 정보

CAS 번호

139667-74-6

Purity

>99%

제형

Solid

form

Molecular weight

384.2 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>Cl<sub>2</sub>NO<sub>4</sub>P

PubChem

132252

Nature

Synthetic

생화학적 명칭

3-[(3,4-Dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid

생물학적 정보

Potent, selective GABAB antagonist (IC50 = 85 nM). Soluble in 1 ml water to give specified mM/ml concentration.

Canonical SMILES

CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O

InChi

InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChiKey

GJZVQXWEIYRHBE-UHFFFAOYSA-N

IUPAC Name

3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

제품 프로토콜

제품이 사용된 논문 (11)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed38839301

2024

Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Margherita Caputo,Daniela Ivanova,Sylvette Chasserot-Golaz,Frédéric Doussau,Anne-Marie Haeberlé,Cathy Royer,Sebahat Ozkan,Jason Ecard,Nicolas Vitale,Michael A Cousin,Petra Tóth,Stéphane Gasman,Stéphane Ory

eLife 8: PubMed31081751

2019

Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Dorgans,Valérie Demais,Yannick Bailly,Bernard Poulain,Philippe Isope,Frédéric Doussau

eLife 7: PubMed29578411

2018

Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Sooyun Kim,Yoonsub Kim,Suk-Ho Lee,Won-Kyung Ho

Cerebral cortex (New York, N.Y. : 1991) 27:903-918 PubMed28119345

2017

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Minge,Oleg Senkov,Rahul Kaushik,Michel K Herde,Olga Tikhobrazova,Andreas B Wulff,Andrey Mironov,Toin H van Kuppevelt,Arie Oosterhof,Gaga Kochlamazashvili,Alexander Dityatev,Christian Henneberger

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:11830-47 PubMed26311767

2015

Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

Applications

Unspecified application

Species

Unspecified reactive species

Vivian M Hernández,Daniel J Hegeman,Qiaoling Cui,Daniel A Kelver,Michael P Fiske,Kelly E Glajch,Jason E Pitt,Tina Y Huang,Nicholas J Justice,C Savio Chan

Journal of neurophysiology 114:1008-21 PubMed26063780

2015

Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Christian Schauer,Tong Tong,Hugues Petitjean,Thomas Blum,Sophie Peron,Oliver Mai,Frank Schmitz,Ulrich Boehm,Trese Leinders-Zufall

Journal of neurophysiology 113:2195-209 PubMed25589590

2015

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Tristan Hedrick,Jack Waters

Frontiers in cellular neuroscience 7:209 PubMed24294191

2013

Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanni Russo,Thierry R Nieus,Silvia Maggi,Stefano Taverna

Cell reports 1:225-33 PubMed22662315

2012

Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Darrin H Brager,Arvin R Akhavan,Daniel Johnston

Nature neuroscience 15:746-53 PubMed22446881

2012

Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Rogier Min,Thomas Nevian
제품이 사용된 논문 모두 보기

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