AB120337

CGP 55845 hydrochloride, GABAB antagonist

Be the first to review this product! 리뷰 제출

(34 제품이 사용된 논문 )

CGP 55845 hydrochloride (CAS:149184-22-5) (ab120337) is a potent, selective GABAB antagonist (IC₅₀ = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). MW 438.7, Purity >98%.

- Proven performance: cited in over 30 publications
- Available in different formats to fit your experimental needs. Larger volume format available upon request.

2 이미지

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

FuncS

PubMed

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

5-CT-activated inwardly rectifying K⁺ conductance in 5-HT neurons displays limited desensitization.

(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT_1A receptor agonist, 5-CT on inwardly rectifying K⁺ conductance (G_{-110/-90 mV}) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K⁺ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.

Montalbano et al PLoS One. 2015 Oct 13;10(10):e0140369. doi: 10.1371/journal.pone.0140369. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

Chemical Structure

Lab

Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist

주요 정보

CAS 번호

149184-22-5

Purity

>98%

제형

Solid

form

Molecular weight

438.7 Da

Molecular formula

C18H23Cl3NO3P

PubChem

9954841

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

CGP 55845 hydrochloride

생물학적 정보

Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.

Canonical SMILES

CC(C1=CC(=C(C=C1)Cl)Cl)NCC(CP(=O)(CC2=CC=CC=C2)O)O.Cl

Isomeric SMILES

C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl

InChi

InChI=1S/C18H22Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1

InChiKey

PXQAIXBYWZBYKJ-LINSIKMZSA-N

IUPAC Name

benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;hydrochloride

style

left-column

style

left-column

style

left-column

특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

Ambient

적절한 장기 보관 조건

Ambient

보관 정보

The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

style

left-column

style

left-column

style

left-column

제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

style

left-column

제품이 사용된 논문 (34)

Recent publications for all applications. Explore the 전체 목록 and refine your search

STAR protocols 5:103255 PubMed39146190

2024

Protocol for electrophysiological measurements of circadian changes in excitability in dentate granule cells from adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Linda Overstreet-Wadiche

eLife 12: PubMed37404129

2023

Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing.

Applications

Unspecified application

Species

Unspecified reactive species

Crescent L Combe,Carol M Upchurch,Carmen C Canavier,Sonia Gasparini

Cell reports 42:112039 PubMed36749664

2023

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Angela M Vincent,Angela L Hill,Lacy K Goode,Gwendalyn D King,Karen L Gamble,Jacques I Wadiche,Linda Overstreet-Wadiche

Cell reports 40:111440 PubMed36170833

2022

Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.

Applications

Unspecified application

Species

Unspecified reactive species

Kathy Z Dai,In Bae Choi,Ryan Levitt,Mariah B Blegen,Alanna R Kaplan,Aya Matsui,J Hoon Shin,Miriam E Bocarsly,Eleanor H Simpson,Christoph Kellendonk,Veronica A Alvarez,Lauren K Dobbs

iScience 25:103922 PubMed35252816

2022

Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.

Applications

Unspecified application

Species

Unspecified reactive species

Poonam Mishra,Rishikesh Narayanan

Cell reports 36:109495 PubMed34348148

2021

Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jingliang Zhang,Xiaoling Chen,Muriel Eaton,Jiaxiang Wu,Zhixiong Ma,Shirong Lai,Anthony Park,Talha S Ahmad,Zhefu Que,Ji Hea Lee,Tiange Xiao,Yuansong Li,Yujia Wang,Maria I Olivero-Acosta,James A Schaber,Krishna Jayant,Chongli Yuan,Zhuo Huang,Nadia A Lanman,William C Skarnes,Yang Yang

Cell reports 33:108338 PubMed33147470

2020

Cerebellum-Specific Deletion of the GABA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Rudolph,Chong Guo,Stan L Pashkovski,Tomas Osorno,Winthrop F Gillis,Jeremy M Krauss,Hajnalka Nyitrai,Isabella Flaquer,Mahmoud El-Rifai,Sandeep Robert Datta,Wade G Regehr

eLife 9: PubMed32496194

2020

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ramesh Chittajallu,Kurt Auville,Vivek Mahadevan,Mandy Lai,Steven Hunt,Daniela Calvigioni,Kenneth A Pelkey,Kareem A Zaghloul,Chris J McBain

Cerebral cortex (New York, N.Y. : 1991) 30:3667-3685 PubMed32080739

2020

Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Luo,Alexandre Guet-McCreight,Vincent Villette,Ruggiero Francavilla,Beatrice Marino,Simon Chamberland,Frances K Skinner,Lisa Topolnik

eLife 9: PubMed32073397

2020

Presynaptic GABA receptors functionally uncouple somatostatin interneurons from the active hippocampal network.

Applications

Unspecified application

Species

Unspecified reactive species

Sam A Booker,Harumi Harada,Claudio Elgueta,Julia Bank,Marlene Bartos,Akos Kulik,Imre Vida

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

CGP 55845 hydrochloride, GABAB antagonist

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

Isomeric SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Biochemicals

Biochemicals

Biochemicals

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (34)

Product promise