CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative

주요 정보

CAS 번호

50-90-8

제형

Solid

form

Molecular weight

262.65 Da

Molecular formula

C₉H₁₁ClN₂O₅

PubChem

65510

Nature

Synthetic

Solubility

Soluble in water

생화학적 명칭

5-Chloro-2'-deoxyuridine

생물학적 정보

Thymidine analogue, readily incorporated following phosphorylation, into newly synthesized DNA in place of thymidine. Used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors.

Canonical SMILES

C1C(C(OC1N2C=C(C(=O)NC2=O)Cl)CO)O

Isomeric SMILES

C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)O

InChi

InChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChiKey

NJCXGFKPQSFZIB-RRKCRQDMSA-N

IUPAC Name

5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione