MW 242.7 Da, Purity >99%. PPARα agonist (EC50 values are 50 and 55 μM at mouse and human receptors respectively). Antihyperlipoproteinemic agent.
대체 명칭 보기
1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, Atherosclerosis, susceptibility to, included, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686N23123, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FABP 1, FABPL_HUMAN, Fatty acid binding protein 1 liver, Fatty acid-binding protein, Fatty acid-binding protein 1, Fatty acid-binding protein liver, Glucocorticoid inducible P450, HDL cholesterol, augmented response of, to hormone replacement, included, HLP, L-FABP, Liver-type fatty acid-binding protein, MGC126680, Myocardial infarction, susceptibility to, included, NF 25, NR3A1, NR3A2, Nifedipine oxidase, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, OTTHUMP00000017718, OTTHUMP00000017719, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, Quinine 3-monooxygenase, RNESTROR, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- Chemical Structure
Lab
Chemical Structure - Clofibrate, PPARalpha agonist (AB141331)
2D chemical structure image of ab141331, Clofibrate, PPARalpha agonist
보완 제품
제품 세부 정보
특성 및 보관 정보
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
취급 방법
Need more advice on solubility, usage and handling? Please visit our our product support page for more details.
|
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
|
Refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Estrogen Receptor influences reproductive tissues and breast development by regulating genes involved in cell growth. It forms complexes with coactivator proteins to modulate transcription. CYP3A4 participates in the metabolism of drugs and steroids affecting their clearance and bioavailability. Liver FABP assists in the intracellular trafficking of lipids and the modulation of lipid levels within hepatocytes which are liver cells.
Pathways
The Estrogen Receptor plays significant roles in the estrogen signaling pathway which involves proteins like coactivators and corepressors influencing cell proliferation and differentiation. CYP3A4 facilitates the drug metabolism pathway interacting with proteins such as cytochrome P450 reductase. These proteins collaborate to metabolize drugs and regulate endogenous steroid levels. Liver FABP is involved in lipid metabolism pathways working with enzymes that process and transport lipids within the liver.
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com