JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB142815

Desformylflustrabromine hydrochloride, alpha4beta2 modulator

Be the first to review this product! 리뷰 제출

|

(0 출판물)

MW 357.7 Da, Purity >98%. Selective positive allosteric nAChR α4β2 modulator (Ki = 3400 nM). Increases whole cell current when co-applied with effective concentrations of ACh. Anti-addictive effects in vivo..

대체 명칭 보기

A4 nicotinic receptor, ACH 4, ACHA4_HUMAN, ACHB2_HUMAN, ACHN, AChR, Acetylcholine receptor alpha 4 neural, Acetylcholine receptor beta 2 neural, Acetylcholine receptor neuronal nicotinic alpha 4 subunit, Acra 4, Acrb 2, Alpha4 nAChR, BFNC, CHRNA 4, Cholinergic receptor nicotinic alpha 4, Cholinergic receptor nicotinic alpha polypeptide 4, Cholinergic receptor nicotinic beta 2, Cholinergic receptor nicotinic beta polypeptide 2, Cholinergic receptor nicotinic beta polypeptide 2 neuronal, Chrnb2, EBN, EBN 1, EFNL 3, NACHR, NACRA 4, Neuronal acetylcholine receptor protein beta 2 chain precursor, Neuronal acetylcholine receptor protein subunit beta 2, Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, Neuronal nicotinic acetylcholine receptor alpha 4 subunit, Neuronal nicotinic acetylcholine receptor beta 2, b2 nAchR, cholinergic receptor, nicotinic, beta 2 (neuronal), nAChRB2

1 이미지
Chemical Structure - Desformylflustrabromine hydrochloride, alpha4beta2 modulator (AB142815)
  • Chemical Structure

Lab

Chemical Structure - Desformylflustrabromine hydrochloride, alpha4beta2 modulator (AB142815)

2D chemical structure image of ab142815, Desformylflustrabromine hydrochloride, alpha4beta2 modulator

주요 정보

CAS 번호

951322-11-5

Purity

>98%

제형

Solid

form

Molecular weight

357.7 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>2</sub>BrClN<sub>2</sub>

PubChem

56675778

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

Desformylflustrabromine Hydrochloride

생물학적 정보

Selective positive allosteric nAChR α4β2 modulator (Ki = 3400 nM). Increases whole cell current when co-applied with effective concentrations of ACh. Anti-addictive effects in vivo.

Canonical SMILES

CC(C)(C=C)C1=C(C2=C(N1)C=C(C=C2)Br)CCNC.Cl

InChi

InChI=1S/C16H21BrN2.ClH/c1-5-16(2,3)15-13(8-9-18-4)12-7-6-11(17)10-14(12)19-15;/h5-7,10,18-19H,1,8-9H2,2-4H3;1H

InChiKey

GEZWEAPBLKXKGN-UHFFFAOYSA-N

IUPAC Name

2-[6-bromo-2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]-N-methylethanamine;hydrochloride

style
left-column

보완 제품

Primary Antibodies

AB179471

Anti-Integrin beta 1 antibody [EPR16895]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 1 antibody [EPR16895] (AB179471)

  • 5
  • 5
Primary Antibodies

AB150361

Anti-Integrin alpha 5 antibody [EPR7854]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-Integrin alpha 5 antibody [EPR7854] (AB150361)

  • 5
  • 13
Primary Antibodies

AB179475

Anti-Integrin alpha V antibody [EPR16800]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-Integrin alpha V antibody [EPR16800] (AB179475)

  • 5
  • 10
Primary Antibodies

AB309092

Anti-Integrin beta 5 antibody [EPR26930-21]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 5 antibody [EPR26930-21] (AB309092)

  • 0
  • 0
style
left-column
style
left-column

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) and beta 2 (CHRNB2) also known as nAChR α4β2 are subunits of a pentameric ligand-gated ion channel. This receptor is involved in neurotransmission by binding with the neurotransmitter acetylcholine causing an ion flow through the channel. The receptor which has a mass of approximately 290 kDa is expressed in the central nervous system particularly in areas such as the cerebral cortex and thalamus. Its expression is important for the modulation of synaptic activity and cognitive functions.
Biological function summary

These nicotinic receptors play a role in the complex of heteromeric assemblies contributing to the regulation of ion influx in neurons. They influence neural excitability and synaptic plasticity impacting processes such as learning and memory. The formation of these receptors requires the assembly of both alpha 4 and beta 2 subunits which dictates the receptor's specific functional properties and pharmacological profile.

Pathways

The nAChR α4β2 receptor significantly contributes to the cholinergic signaling pathway. This pathway is critical in mediating responses to the neurotransmitter acetylcholine in both the autonomic nervous system and the central nervous system. The receptor interacts with other proteins such as GABA receptors influencing neurotransmitter release which integrates into the network of choline metabolism and signaling processes.

Mutations or dysfunction in the nAChR α4β2 receptor associate with neurological conditions like epilepsy and Alzheimer's disease. For instance mutations in CHRNA4 can lead to autosomal dominant nocturnal frontal lobe epilepsy. The altered receptor function can disrupt normal neural communication resulting in the symptoms observed in these disorders. The receptor's interactions with other proteins like the dopamine transporter further link it to conditions such as nicotine addiction and reward pathways.
style
left-column
style
left-column

제품 프로토콜

style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com