Dexrazoxane hydrochloride, Topoisomerase II inhibitor

주요 정보

CAS 번호

24584-09-6

Purity

>98%

제형

Solid

form

Molecular weight

268.27 Da

Molecular formula

C₁₁H₁₆N₄O₄

PubChem

71384

Nature

Synthetic

Solubility

0.1 M Borate Buffer (pH 9) 8.7 - 13 (mg/mL)

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

생화학적 명칭

Dexrazoxane

생물학적 정보

Topoisomerase II inhibitor. Intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters. Reduces ROS° production and activates the PI3K/Akt survival pathway. Cardioprotective effects when co-administered with doxorubicin (ab142006) in vivo.

Canonical SMILES

CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Isomeric SMILES

C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

InChi

InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChiKey

BMKDZUISNHGIBY-ZETCQYMHSA-N

IUPAC Name

4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione