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AB141278

Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor

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MW 528.5 Da, Purity >99%. Selective, competitive dual 5α reductase type 1 and type 2 inhibitor. Blocks the conversion of testosterone into dihydrotestosterone. Shows antitumor effects in vivo. Orally active.

대체 명칭 보기

ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, AIS, ANDR_HUMAN, AR, AR8, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), BRIC2, Bile salt export pump, Bsep, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, GCCR, GCRST, GCR_HUMAN, GLRA1_HUMAN, GR, Glucocorticoid receptor, Glycine receptor 48 kDa subunit, Glycine receptor alpha 1, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, Glycine receptor, alpha 1 subunit, Grl1, H-ERG, HKPX1, HUMARA, HYSP1, KCNH2_HUMAN, KD, Kennedy disease (KD), Kv11.1, LQT 2, NR3C4, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), PFIC 2, PGY4, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, SBMA, SMAX1, SQT1, STHE, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, Testicular Feminization (TFM), Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, androgen receptor splice variant 4b, eag homolog, glucocorticoid nuclear receptor variant 1, hERG-1, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), progressive familial intrahepatic cholestasis 2

1 이미지
Chemical Structure - Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor (AB141278)
  • Chemical Structure

Lab

Chemical Structure - Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor (AB141278)

2D chemical structure image of ab141278, Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor

주요 정보

CAS 번호

164656-23-9

Purity

>99%

제형

Solid

form

Molecular weight

528.5 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>0</sub>F<sub>6</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

6918296

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

생화학적 명칭

Dutasteride

생물학적 정보

Selective, competitive dual 5α reductase type 1 and type 2 inhibitor. Blocks the conversion of testosterone into dihydrotestosterone. Shows antitumor effects in vivo. Orally active.

Canonical SMILES

CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C

Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C

InChi

InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChiKey

JWJOTENAMICLJG-QWBYCMEYSA-N

IUPAC Name

(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

제품 프로토콜

Product promise

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