AB120214

Exendin-4 (Exenatide), GLP-1 receptor agonist

Name: Exendin-4 (Exenatide), GLP-1 receptor agonist
Brand: Abcam Limited
SKU: AB120214
Rating: 5 (1 reviews)

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(6 제품이 사용된 논문 )

Exendin-4 (Exenatide)(CAS: 141758-74-9)(ab120214) is a incretin mimetic and composed of 39 amino acids. Exendin-4 is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. MW 4187.

- Available in different sizes to fit your experimental needs. Larger volume format available upon request

1 이미지

Chemical Structure - Exendin-4 (Exenatide), GLP-1 receptor agonist (AB120214)

Chemical Structure

Lab

Chemical Structure - Exendin-4 (Exenatide), GLP-1 receptor agonist (AB120214)

2D chemical structure image of ab120214, Exendin-4 (Exenatide), GLP-1 receptor agonist

주요 정보

CAS 번호

141758-74-9

Purity

>95%

제형

Solid

form

Formulation

Constituents: 95% Exendin 3 (Heloderma horridum), 2-glycine-3-L-glutamic acid-

Molecular weight

4187 Da

Molecular formula

C184H282N50O60S

PubChem

45588096

Nature

Synthetic

Solubility

Soluble in water

생화학적 명칭

Exenatide

Canonical SMILES

CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(=O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(

Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC9=CNC=N9)N

InChi

InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1

InChiKey

HTQBXNHDCUEHJF-XWLPCZSASA-N

IUPAC Name

(4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]acetyl]amino]-5-oxopentanoic acid

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제품 세부 정보

Check out our range of GLP-1 biochemicals here

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

-20°C

적절한 장기 보관 조건

-20°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please refer to our product support page for more details on handling.

Need more advice on solubility, usage and handling? Please visit our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록and refine your search

Nature communications 15:4687 PubMed38824166

2024

Highly biased agonism for GPCR ligands via nanobody tethering.

Applications

Unspecified application

Species

Unspecified reactive species

Shivani Sachdev,Brendan A Creemer,Thomas J Gardella,Ross W Cheloha

The Journal of endocrinology 259: PubMed37466202

2023

The GLP-1 agonist, exendin-4, stimulates LH secretion in female sheep.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth M Simpson,Iain J Clarke,Christopher J Scott,Cyril P Stephen,Alexandra Rao,Allan J Gunn

Frontiers in physiology 12:648399 PubMed34054568

2021

High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction Inhibition of β-Arrestin-Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xietian Pan,Chengxiang Li,Haokao Gao

Naunyn-Schmiedeberg's archives of pharmacology 393:1303-1311 PubMed32363414

2020

Reduction of hippocampal IL-6 levels in LPS-injected rats following acute exendin-4 treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Luiza P Géa,Eduarda D da Rosa,Bruna S Panizzutti,Érica Z de Aguiar,Larissa F de Oliveira,Pamela Ferrari,Angelo Piato,Rosane Gomez,Rafael Colombo,Adriane R Rosa

Diabetes, metabolic syndrome and obesity : targets 12:2289-2302 PubMed31807042

2019

Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xietian Pan,Jiangwei Chen,Tingting Wang,Mingming Zhang,Haichang Wang,Haokao Gao

American journal of physiology. Regulatory, integr 315:R595-R608 PubMed29949410

2018

Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob D Brown,Danielle McAnally,Jennifer E Ayala,Melissa A Burmeister,Camilo Morfa,Layton Smith,Julio E Ayala

제품이 사용된 논문 모두 보기

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Exendin-4 (Exenatide), GLP-1 receptor agonist

Chemical Structure - Exendin-4 (Exenatide), GLP-1 receptor agonist (AB120214)

주요 정보

CAS 번호

Purity

제형

Formulation

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

Canonical SMILES

Isomeric SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Reagents, Controls & Accessories

Primary Antibodies

Assay Kits

제품 세부 정보

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

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보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (6)

Product promise