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AB146169

Ferrostatin 1, erastin-induced ferroptosis inhibitor

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(4 제품이 사용된 논문 )

MW 262.35 g/mol. Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
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Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (AB146169)
  • Chemical Structure

Lab

Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (AB146169)

2D chemical structure image of ab146169, Ferrostatin 1, erastin-induced ferroptosis inhibitor

주요 정보

CAS 번호

347174-05-4

제형

Solid

form

Molecular weight

262.35 g/mol

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO (up to 100 mg/ml)

Soluble in Ethanol (up to 100 mg/ml)

생물학적 정보

Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.

Canonical SMILES

O=C(OCC)C2CCC(NC1CCCCC1)C(N)C2

InChi

InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChiKey

UJHBVMHOBZBWMX-UHFFFAOYSA-N

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보완 제품

Biochemicals

AB285437

RSL3

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Biochemicals

AB120727

Deferoxamine mesylate, Iron chelator

Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)

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Biochemicals

AB141053

Necrostatin-1, necroptosis inhibitor

Functional Studies - Necrostatin-1, necroptosis inhibitor (AB141053)

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Biochemicals

AB209693

Erastin, ferroptosis activator

Chemical Structure - Erastin, ferroptosis activator (AB209693)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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제품 프로토콜

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death and differentiation 32:1679-1690 PubMed40188196

2025

GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Zixiang Chen,Kaifeng Niu,Mengge Li,Yuchun Deng,Ji Zhang,Di Wei,Jiaqi Wang,Yongliang Zhao

Redox biology 79:103479 PubMed39742570

2025

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaifeng Niu,Zixiang Chen,Mengge Li,Guannan Ma,Yuchun Deng,Ji Zhang,Di Wei,Jiaqi Wang,Yongliang Zhao

Cell death & disease 13:662 PubMed35906211

2022

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim Fandrey

Cell 171:628-641.e26 PubMed29053969

2017

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Applications

Unspecified application

Species

Unspecified reactive species

Sally E Wenzel,Yulia Y Tyurina,Jinming Zhao,Claudette M St Croix,Haider H Dar,Gaowei Mao,Vladimir A Tyurin,Tamil S Anthonymuthu,Alexandr A Kapralov,Andrew A Amoscato,Karolina Mikulska-Ruminska,Indira H Shrivastava,Elizabeth M Kenny,Qin Yang,Joel C Rosenbaum,Louis J Sparvero,David R Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C Watkins,Theodore R Holman,Andrew P VanDemark,John A Kellum,Ivet Bahar,Hülya Bayır,Valerian E Kagan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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