FFN511, Fluorescent substrate for VMAT2

주요 정보

CAS 번호

1004548-96-2

Purity

>98%

제형

Solid

form

Molecular weight

284.35 Da

Molecular formula

C₁₇H₂₀N₂O₂

PubChem

23725121

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

생화학적 명칭

False Fluorescent Neurotransmitter 511, FFN-511

생물학적 정보

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.
Inhibits 5-HT binding to VMAT2 (IC₅₀ = 1 μM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparation. Labels dopamine and other presynaptic terminals in the striatum.
Compatible with GFP tags and other optical probes. Sufficiently bright, photostable and suitable for two-photon fluorescence microscopy.
View the technique online

For highly selective labelling of dopaminergic presynaptic termainals FFN102 (ab120866) is recommended.

Canonical SMILES

C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN

InChi

InChI=1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2

InChiKey

SKTIZSRPCXRDHX-UHFFFAOYSA-N

IUPAC Name

6-(2-aminoethyl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2(7),5,8-tetraen-4-one