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AB141049

Genipin, Cell-permeable uncoupling protein 2 inhibitor

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MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
2 이미지
Functional Studies - Genipin, Cell-permeable uncoupling protein 2 inhibitor (AB141049)
  • FuncS

Unknown

Functional Studies - Genipin, Cell-permeable uncoupling protein 2 inhibitor (AB141049)

ab28 staining p53 in HeLa cells treated with genipin (ab141049), by ICC/IF. Increase of p53 expression correlates with increased concentration of genipin, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141049 (genipin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab28 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Genipin, Cell-permeable uncoupling protein 2 inhibitor (AB141049)
  • Chemical Structure

Lab

Chemical Structure - Genipin, Cell-permeable uncoupling protein 2 inhibitor (AB141049)

2D chemical structure image of ab141049, Genipin, Cell-permeable uncoupling protein 2 inhibitor

주요 정보

CAS 번호

6902-77-8

Purity

>99%

제형

Solid

form

Molecular weight

226.23 g/mol

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>4</sub>O<sub>5</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

생물학적 정보

Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.

Isomeric SMILES

O=C(OC)C1=CO[C@@H](O)[C@@H]2C(=CC[C@H]12)CO

InChi

InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1

InChiKey

AZKVWQKMDGGDSV-BCMRRPTOSA-N

IUPAC Name

(1R,4aS,7aS)-1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester

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보완 제품

Primary Antibodies

AB125011

Anti-TSG101 antibody [EPR7130(B)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry - Anti-TSG101 antibody [EPR7130(B)] (AB125011)

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Assay Kits

AB245880

H&E Staining Kit (Hematoxylin and Eosin)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - H&E Staining Kit (Hematoxylin and Eosin) (AB245880)

  • 5
  • 3
Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

20ul selling size|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

  • 3
  • 6
Primary Antibodies

AB79559

Anti-CD81 antibody [M38]

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD81 antibody [M38] (AB79559)

  • 4
  • 2
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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제품 프로토콜

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Product promise

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