GSK2578215A, LRRK2 inhibitor

주요 정보

CAS 번호

1285515-21-0

Purity

>98%

제형

Solid

form

Molecular weight

399.4 Da

Molecular formula

C₂₄H₁₈FN₃O₂

PubChem

68107965

Nature

Synthetic

Solubility

Soluble in DMSO to >75 mM

생화학적 명칭

Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-

생물학적 정보

Potent and highly selective LRRK2 inhibitor (IC₅₀ = 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively). Selective for LRRK2 in a panel of 460 kinases. Blood-brain barrier (BBB) permeable.

Canonical SMILES

C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

InChi

InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)

InChiKey

WCIGMFCFPXZRMQ-UHFFFAOYSA-N

IUPAC Name

5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide