MW 327.8 Da, Purity >98%. ROCK2 inhibitor (IC50 = 1.9 μM). Also shown to inhibit PRK2 (IC50 = 4 μM), MSK1 (IC50 = 5 μM), Rsk2 (IC50 = 15 μM), PKA, p70 S6 Kinase, CaM Kinase and MLCK. Calcium antagonist and vasodilator.
대체 명칭 보기
ACLS, AI256365, AIS, ANDR_HUMAN, AR, AR8, ARO, ARO1, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Aromatase, Atherosclerosis, susceptibility to, included, C-C CKR-2, C-C chemokine receptor type 2, C430023I11Rik, CAR, CAR BETA, CARA, CCR1L, CCR2A, CCR2B, CCR2_HUMAN, CCR5L, CD192, CD192 antigen, CKR 2, CKR2A, CKR2B, CMKBR2, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Car 1, Chemokine C C motif receptor 2, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), EC 2.7.1.37, ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HD protein, HDH, HDL cholesterol, augmented response of, to hormone replacement, included, HD_HUMAN, HUMARA, HUNTINGTON CHOREA, HYSP1, Huntingtin, Huntington disease protein, Huntington's disease protein homolog, Hypothetical protein FLJ35932, IT 15, KD, KIAA0619, Kennedy disease (KD), MB67, MCP-1-R, MCP1 RECEPTOR, MGC104309, MGC97144, Microsomal monooxygenase, Monocyte Chemotactic Protein 1 Receptor, Monocyte chemoattractant protein 1 receptor, Myocardial infarction, susceptibility to, included, NR1B1, NR1I3_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000162543, OTTHUMP00000198350, OTTMUSP00000026909, Oncogene GLI3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, P 450AROM, PAP A, PAPB, PPD IV, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, RNESTROR, ROCK2_HUMAN, ROK alpha, Renal carcinoma antigen NY-REN-35, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Rho associated coiled coil containing protein kinase 1, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase 2, Rho-associated, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Rock II, Rock2m, SBMA, SMAX1, STK33_HUMAN, Serine threonine kinase 33, Serine/threonine kinase 33, Serine/threonine-protein kinase 33, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, ZHD, Zinc finger protein GLI 3, androgen receptor splice variant 4b, coiled-coil-containing protein kinase 2, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, orphan nuclear hormone receptor, p160 ROCK, p160 ROCK-1, p164 ROCK-2
- FuncS
Unknown
Functional Studies - HA-1077 (Fasudil), ROCK2 inhibitor (AB120306)
ab46154 staining VEGF in MCF7 cells treated with HA 1077 (ab120306), by ICC/IF. Decrease in VEGF expression correlates with increased concentration of HA 1077 as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120306 (HA 1077) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab46154 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
- Chemical Structure
Lab
Chemical Structure - HA-1077 (Fasudil), ROCK2 inhibitor (AB120306)
2D chemical structure image of ab120306, HA-1077 (Fasudil), ROCK2 inhibitor
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