Ibrutinib (PCI-32765), BTK inhibitor

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MW 440.5 Da, Purity >99%. Highly potent, irreversible Bruton tyrosine kinase (BTK) inhibitor (IC₅₀ = 0.5nM). Inhibits autophosphorylation of BTK IC₅₀ = 11 nM), and phophorylation of PLCγ (IC₅₀ = 29 nM) and ERK (IC₅₀ = 13 nM). Potently inhbits BLK, BMS, FGR, EGFR and ITK kinases. Blocks B-cell antigen receptor (BCR) activation. Cytotoxic to chronic lymphocytic leukemia (CLL) cells.

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AA407514, AGMX 1, AI838772, AT, ATK, AW493413, Agammaglobulinaemia tyrosine kinase, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, B lymphocyte kinase, B lymphoid tyrosine kinase, B-cell progenitor kinase, BBDS, BEK, BEK fibroblast growth factor receptor, BFR1, BLK nonreceptor tyrosine kinase, BLK_HUMAN, BMX non receptor tyrosine kinase, BMX_HUMAN, BONE MARROW KINASE, X-LINKED, BPK, BTK_HUMAN, Bone marrow tyrosine kinase gene in chromosome X protein, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton闂佺偨鍎查悰 Tyrosine Kinase, C ret, CD 135, CD135 antigen, CD332, CD332 antigen, CDHF 12, CDHR16, CEK3, CFD1, Cadherin family member 12, Cadherin related family member 16, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, Cellular Yes 1 protein, Craniofacial dysostosis 1, Cytoplasmic tyrosine-protein kinase BMX, DKFZP586N0721, DKFZp686J10186, EC 2.7.10.2, ECT1, EGFR_HUMAN, ELKS Fusion gene, ERBB, ERBB1, ETK, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Epithelial and endothelial tyrosine kinase, Errp, FGF receptor, FGFR2_HUMAN, FL cytokine receptor, FLJ11090, FLJ26625, FLT3_HUMAN, Fetal liver kinase 2, Fibroblast growth factor receptor 2, Flk 2, Fms related tyrosine kinase 3, Fms-like tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, HER1, HSCR 1, HSPC193, HST17436, Hck 2, HsT441, IMD 1, JTK 8, JV15-2, JWS, Jackson Weiss syndrome, K-sam, KGFR, Keratinocyte growth factor receptor, Keratinocyte growth factor receptor 2, LDS1C, LDS3, LYN proto oncogene, Src family tyrosine kinase, LYN_HUMAN, Lck/Yes related novel protein tyrosine kinase, Ly-72, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, MAD, mothers against decapentaplegic homolog 3, MADH 3, MEN2A, MEN2B, MGC 10442, MGC104252, MGC112732, MGC126261, MGC126262, MGC60396, MODY 11, MTC 1, Mad homolog JV15 2, Mad protein homolog, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, NISBD2, NKT38, NTK 38, ONCOGENE LYN, OTTHUMP0000004234, OTTHUMP00000063593, Oncogen ERBB, Oncogene RET, PIG61, PSCTK 1, PSCTK 2, PSCTK 3, PTC, Protein tyrosine kinase BMX, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-ErbB-1, Proto-oncogene c-Ret, Proto-oncogene c-Yes, Proto-oncogene tyrosine-protein kinase receptor ret, RET ELE1, RET transforming sequence, RET51, RET9, RET_HUMAN, RP24-311F12.2, Receptor type tyrosine protein kinase FLT3, Receptor tyrosine-protein kinase ErbB-1, Ret Proto oncogene, SA7, SCAN1, SMA and MAD related protein 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, SMAD3_HUMAN, STK-1, Species antigen 7, Stem cell tyrosine kinase 1, TK14, TK25, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosine kinase B lymphocyte specific, Tyrosine protein kinase, Tyrosine-protein kinase BLK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Yes, Tyrosine-protein kinase receptor FLT3, Tyrosyl-DNA phosphodiesterase 1, Urogastrone, V yes 1 Yamaguchi sarcoma viral related oncogene homolog, Viral oncogene yes 1 homolog 1, Wa5, XLA, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yamaguchi sarcoma viral (v yes 1) related oncogene homolog, Yes 1, bacteria-expressed kinase, c Yes, dominant-negative kinase-deficient Brutons tyrosine kinase, erb-b2 receptor tyrosine kinase 1, hMAD-3, hSMAD3, hydroxyaryl-protein kinase, mENA, p53Lyn, p55-BLK, p56Lyn, p61-Yes, protein tyrosine kinase, receptor like 14, soluble FGFR4 variant 4, truncated Bruton agammaglobulinemia tyrosine kinase, tyrosine-protein kinase BTK isoform (lacking exon 14, tyrosine-protein kinase receptor ret, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2