IEM-1460, GluR2 lacking AMPA receptor blocker

주요 정보

CAS 번호

121034-89-7

제형

Solid

form

Molecular weight

454.3 Da

Molecular formula

C₁₉H₃₈Br₂N₂

PubChem

6604954

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

생화학적 명칭

5-(1-Adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide

생물학적 정보

Selective, Ca²⁺ permeable GluR2-lacking AMPA receptor blocker (IC₅₀ values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.

Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical SMILES

C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

InChi

InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1

InChiKey

CQTDZUSQSTUZDA-UHFFFAOYSA-M

IUPAC Name

5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide