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AB144653

JZL 195 hydrochloride, FAAH/MAGL inhibitor

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MW 433.5 Da, Purity >99%. Potent dual FAAH/MAGL inhibitor. Shows analgesic effects in vivo. Centrally active. Blood-brain barrier permeable.

대체 명칭 보기

0610041D24Rik, 2 arachidonoylglycerol hydrolase, AA673485, AV065425, Abhydrolase domain containing 6, Abhydrolase domain containing protein 6, Anandamide amidohydrolase, Anandamide amidohydrolase 1, EC 3.1.1.23, FA2H, FAAH, FAAH1_HUMAN, Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, Fatty acid amide hydrolase, Fatty-acid amide hydrolase 1, HU-K5, Llipase protein, Lysophospholipase homolog, Lysophospholipase-like, MAGL, MGC102823, MGC138146, MGC94917, MGL, MGLL_HUMAN, Monoacylglycerol lipase, Monoglyceride lipase, Oleamide hydrolase, Oleamide hydrolase 1

1 이미지
Chemical Structure - JZL 195 hydrochloride, FAAH/MAGL inhibitor (AB144653)
  • Chemical Structure

Lab

Chemical Structure - JZL 195 hydrochloride, FAAH/MAGL inhibitor (AB144653)

2D chemical structure image of ab144653, JZL 195 hydrochloride, FAAH/MAGL inhibitor

주요 정보

CAS 번호

1210004-12-8

Purity

>99%

제형

Solid

form

Molecular weight

433.5 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>3</sub>N<sub>3</sub>O<sub>5</sub>

PubChem

46232606

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

(4-Nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate

생물학적 정보

Potent dual FAAH/MAGL inhibitor. Shows analgesic effects in vivo. Centrally active. Blood-brain barrier permeable.

Canonical SMILES

C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]

InChi

InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2

InChiKey

QNYRAEKLMNDRFY-UHFFFAOYSA-N

IUPAC Name

(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate

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보완 제품

Biochemicals

AB278074

4'-hydroxyazobenzene-2-carboxylic acid (HABA)

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Biochemicals

AB141105

SB 408124, non-peptide OX1 antagonist

Chemical Structure - SB 408124, non-peptide OX1 antagonist (AB141105)

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Biochemicals

AB146147

NKY 80, adenylyl cyclase 5 inhibitor

Chemical Structure - NKY 80, adenylyl cyclase 5 inhibitor (AB146147)

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Biochemicals

AB120923

Leelamine, Pyruvate dehydrogenase kinase (PDK) inhibitor

Chemical Structure - Leelamine, Pyruvate dehydrogenase kinase (PDK) inhibitor (AB120923)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Monoacylglycerol lipase (MGL) also known as FAAH1 or ABHD6 breaks down monoacylglycerols into free fatty acids and glycerol. This enzyme specifically hydrolyzes the monoacylglycerol 2-arachidonoylglycerol an important precursor in lipid signaling pathways. MGL weighs approximately 33 kDa and is highly expressed in the brain liver and adipose tissues. Its activity directly affects the cellular levels of endocannabinoids and plays a significant role in lipid metabolism.
Biological function summary

The enzyme influences cannabinoid and eicosanoid pathways impacting various physiological systems. MGL operates as a single enzyme but works alongside other lipid enzymes in a complex cellular environment to regulate endocannabinoid signaling. It controls the termination of endocannabinoid signals which are involved in pain mood and appetite regulation. The coordination of its activity with enzymes like FAAH/MGL dual inhibitor provides a check on the metabolism of endocannabinoids maintaining balance within the system.

Pathways

The enzyme is an important player in the endocannabinoid and prostaglandin pathways. Its function relates significantly to the catabolic control of 2-arachidonoylglycerol a process interlinked with FAAH enzyme activity. MGL manages the breakdown while FAAH and MAGL inhibitors can modulate this process affecting the production of pro-inflammatory eicosanoids. These pathways contribute to a wide range of physiological processes including pain response and inflammation management.

The target associates with neurodegenerative diseases and inflammation-related conditions. Altered MGL activity links to disorders like Alzheimer's disease where the enzyme's dysregulation can exacerbate neuroinflammation due to unchecked pro-inflammatory lipid mediators. The enzyme is also involved in obesity-related disorders through its impact on lipid accumulation. Disruption in the balance of MGL and related enzymes affects the endocannabinoid system triggering pathways that contribute to these conditions.
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제품 프로토콜

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Product promise

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