MCAAD-3, Near-infrared probe for imaging of amyloid plaques

주요 정보

CAS 번호

1625629-51-7

Purity

>99%

제형

Solid

form

Molecular weight

282.34 g/mol

Molecular formula

C₁₇H₁₈N₂O₂

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생물학적 정보

Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Isomeric SMILES

CN(C)C1CCC(/C=C/C=C/C=C(/C#N)C(=O)OC)CC1

InChi

InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8-

IUPAC Name

methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate