AB146819

MitoPQ, mitochondria-targeted redox cycler

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(12 제품이 사용된 논문 )

MitoPQ/ MitoParaquat (ab146819) is a mitochondria-targeted redox cycler that selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Molecular weight (MW): 954.5; Purity>98%.

- Available in different sizes to fit your experimental needs

1 이미지

Chemical Structure - MitoPQ, mitochondria-targeted redox cycler (AB146819)

Chemical Structure

Lab

Chemical Structure - MitoPQ, mitochondria-targeted redox cycler (AB146819)

2D chemical structure image of ab146819, MitoPQ, mitochondria-targeted redox cycler

주요 정보

CAS 번호

1821370-28-8

Purity

>98%

제형

Solid

form

Molecular weight

954.5 Da

Molecular formula

C39H46I3N2P

PubChem

129909777

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

생화학적 명칭

MitoPQ

생물학적 정보

Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.

Canonical SMILES

C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]

InChi

InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3

InChiKey

AOZZGHKENAZYTD-UHFFFAOYSA-K

IUPAC Name

10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium;triiodide

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특성 및 보관 정보

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store under desiccating conditions

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (12)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC complementary medicine and therapies 25:175 PubMed40369535

2025

A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Ulrike Weissenstein,Sibylle Tschumi,Bettina Leonhard,Stephan Baumgartner

Science advances 10:eadq4461 PubMed39475607

2024

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Matteo Fiorenza,Johan Onslev,Carlos Henríquez-Olguín,Kaspar W Persson,Sofie A Hesselager,Thomas E Jensen,Jørgen F P Wojtaszewski,Morten Hostrup,Jens Bangsbo

Nature 620:881-889 PubMed37558878

2023

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Liliana M Sanmarco,Joseph M Rone,Carolina M Polonio,Gonzalo Fernandez Lahore,Federico Giovannoni,Kylynne Ferrara,Cristina Gutierrez-Vazquez,Ning Li,Anna Sokolovska,Agustin Plasencia,Camilo Faust Akl,Payal Nanda,Evelin S Heck,Zhaorong Li,Hong-Gyun Lee,Chun-Cheih Chao,Claudia M Rejano-Gordillo,Pedro H Fonseca-Castro,Tomer Illouz,Mathias Linnerbauer,Jessica E Kenison,Rocky M Barilla,Daniel Farrenkopf,Nikolas A Stevens,Gavin Piester,Elizabeth N Chung,Lucas Dailey,Vijay K Kuchroo,David Hava,Michael A Wheeler,Clary Clish,Roni Nowarski,Eduardo Balsa,Jose M Lora,Francisco J Quintana

Frontiers in immunology 13:918551 PubMed36248901

2022

Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Gisela Jimenez-Duran,Joseph Kozole,Rachel Peltier-Heap,Eleanor R Dickinson,Christopher R Kwiatkowski,Francesca Zappacosta,Roland S Annan,Nicholas W Galwey,Eva-Maria Nichols,Louise K Modis,Martha Triantafilou,Kathy Triantafilou,Lee M Booty

Cell stem cell 29:1315-1332.e9 PubMed35998642

2022

The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole Baker,Steven Wade,Matthew Triolo,John Girgis,Damian Chwastek,Sarah Larrigan,Peter Feige,Ryo Fujita,Colin Crist,Michael A Rudnicki,Yan Burelle,Mireille Khacho

Cell reports 34:108723 PubMed33535038

2021

An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Pedro Gonzalez-Menendez,Manuela Romano,Hongxia Yan,Ruhi Deshmukh,Julien Papoin,Leal Oburoglu,Marie Daumur,Anne-Sophie Dumé,Ira Phadke,Cédric Mongellaz,Xiaoli Qu,Phuong-Nhi Bories,Michaela Fontenay,Xiuli An,Valérie Dardalhon,Marc Sitbon,Valérie S Zimmermann,Patrick G Gallagher,Saverio Tardito,Lionel Blanc,Narla Mohandas,Naomi Taylor,Sandrina Kinet

Scientific reports 11:855 PubMed33441602

2021

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Shady Estfanous,Kathrin Krause,Midhun N K Anne,Mostafa Eltobgy,Kyle Caution,Arwa Abu Khweek,Kaitlin Hamilton,Asmaa Badr,Kylene Daily,Cierra Carafice,Daniel Baetzhold,Xiaoli Zhang,Tianliang Li,Haitao Wen,Mikhail A Gavrilin,Hesham Haffez,Sameh Soror,Amal O Amer

Redox biology 34:101547 PubMed32388269

2020

The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Marta Bogacz,Natalie Dirdjaja,Benedikt Wimmer,Carina Habich,R Luise Krauth-Siegel

Cell 177:1201-1216.e19 PubMed31031005

2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Applications

Unspecified application

Species

Unspecified reactive species

Denis A Mogilenko,Joel T Haas,Laurent L'homme,Sébastien Fleury,Sandrine Quemener,Matthieu Levavasseur,Coralie Becquart,Julien Wartelle,Alexandra Bogomolova,Laurent Pineau,Olivier Molendi-Coste,Steve Lancel,Hélène Dehondt,Celine Gheeraert,Aurelie Melchior,Cédric Dewas,Artemii Nikitin,Samuel Pic,Nabil Rabhi,Jean-Sébastien Annicotte,Seiichi Oyadomari,Talia Velasco-Hernandez,Jörg Cammenga,Marc Foretz,Benoit Viollet,Milica Vukovic,Arnaud Villacreces,Kamil Kranc,Peter Carmeliet,Guillemette Marot,Alexis Boulter,Simon Tavernier,Luciana Berod,Maria P Longhi,Christophe Paget,Sophie Janssens,Delphine Staumont-Sallé,Ezra Aksoy,Bart Staels,David Dombrowicz

Cell chemical biology 26:449-461.e8 PubMed30713096

2019

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Lee M Booty,Justyna M Gawel,Filip Cvetko,Stuart T Caldwell,Andrew R Hall,John F Mulvey,Andrew M James,Elizabeth C Hinchy,Tracy A Prime,Sabine Arndt,Cristiane Beninca,Thomas P Bright,Menna R Clatworthy,John R Ferdinand,Hiran A Prag,Angela Logan,Julien Prudent,Thomas Krieg,Richard C Hartley,Michael P Murphy

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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MitoPQ, mitochondria-targeted redox cycler

Chemical Structure - MitoPQ, mitochondria-targeted redox cycler (AB146819)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Primary Antibodies

Assay Kits

Primary Antibodies

Assay Kits

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (12)

Product promise