AB144486

MTEP hydrochloride (mM/ml), mGlu5 antagonist

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(13 제품이 사용된 논문 )

MW 236.72 Da, Purity >99%. Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.

대체 명칭 보기

GLUR, Smp_128940

1 이미지

Chemical Structure - MTEP hydrochloride (mM/ml), mGlu5 antagonist (AB144486)

Chemical Structure

Lab

Chemical Structure - MTEP hydrochloride (mM/ml), mGlu5 antagonist (AB144486)

2D chemical structure image of ab144486, MTEP hydrochloride (mM/ml), mGlu5 antagonist

주요 정보

CAS 번호

1186195-60-7

Purity

>99%

제형

Solid

form

Molecular weight

236.72 Da

Molecular formula

C11H9ClN2S

PubChem

45073467

Nature

Synthetic

생화학적 명칭

MTEP hydrochloride

생물학적 정보

Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical SMILES

CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl

InChi

InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H

InChiKey

YCIOJDKGCWAHLR-UHFFFAOYSA-N

IUPAC Name

2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole;hydrochloride

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (13)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in pharmacology 2:93 PubMed22232603

2012

Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.

Applications

Unspecified application

Species

Unspecified reactive species

Richard M Cleva,Lucas R Watterson,Meagan A Johnson,M Foster Olive

ACS chemical neuroscience 2:471-482 PubMed21927650

2011

(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.

Applications

Unspecified application

Species

Unspecified reactive species

Craig W Lindsley,Brittney S Bates,Usha N Menon,Satyawan B Jadhav,Alexander S Kane,Carrie K Jones,Alice L Rodriguez,P Jeffrey Conn,Christopher M Olsen,Danny G Winder,Kyle A Emmitte

Pharmacology, biochemistry, and behavior 99:619-25 PubMed21703298

2011

Behavioral consequences of the mGlu5 receptor antagonist MTEP in immature rats.

Applications

Unspecified application

Species

Unspecified reactive species

Kateřina Tichá,Anna Mikulecká,Pavel Mareš

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:8669-80 PubMed21653871

2011

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Adam C Errington,Giuseppe Di Giovanni,Vincenzo Crunelli,David W Cope

Pharmacological reports : PR 62:1051-61 PubMed21273662

2011

Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Helena Domin,Barbara Zięba,Krystyna Gołembiowska,Magdalena Kowalska,Anna Dziubina,Maria Śmiałowska

Nature neuroscience 13:1216-24 PubMed20852624

2010

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

Applications

Unspecified application

Species

Unspecified reactive species

Jihoon Jo,Gi Hoon Son,Bryony L Winters,Myung Jong Kim,Daniel J Whitcomb,Bryony A Dickinson,Youn-Bok Lee,Kensuke Futai,Mascia Amici,Morgan Sheng,Graham L Collingridge,Kwangwook Cho

Epilepsia 51 Suppl 3:24-6 PubMed20618395

2010

Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

Applications

Unspecified application

Species

Unspecified reactive species

Pavel Mares,Anna Mikulecká,Katerina Tichá,Denisa Lojková-Janecková,Hana Kubová

British journal of pharmacology 159:534-42 PubMed20067474

2010

Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.

Applications

Unspecified application

Species

Unspecified reactive species

C L Adams,J L Short,A J Lawrence

The Journal of neuroscience : the official journal of the Society for Neuroscience 29:9582-91 PubMed19641121

2009

Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Joyce Besheer,Julie J M Grondin,Michael C Salling,Marina Spanos,Rebekah A Stevenson,Clyde W Hodge

Neurobiology of learning and memory 92:460-3 PubMed19439188

2009

Metabotropic glutamate receptor 5 in conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

A Simonyi,P Serfozo,K E Parker,A K Ramsey,T R Schachtman

제품이 사용된 논문 모두 보기

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Product promise

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MTEP hydrochloride (mM/ml), mGlu5 antagonist

Chemical Structure - MTEP hydrochloride (mM/ml), mGlu5 antagonist (AB144486)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

생화학적 명칭

생물학적 정보

Canonical SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Biochemicals

Assay Kits

Biochemicals

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (13)

Product promise