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AB120026

N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.

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MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
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Chemical Structure - N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (AB120026)
  • Chemical Structure

Lab

Chemical Structure - N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (AB120026)

2D chemical structure image of ab120026, N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.

주요 정보

Purity

>99%

제형

Solid

form

Molecular weight

312.8 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>7</sub>ClN<sub>4</sub>

PubChem

2820

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

CID 2820

생물학적 정보

Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.

Canonical SMILES

C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Isomeric SMILES

C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

InChi

InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2

InChiKey

HESZUPIXRNZIOI-UHFFFAOYSA-N

IUPAC Name

3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine

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보완 제품

Biochemicals

AB120019

Clozapine, Atypical antipsychotic

Chemical Structure - Clozapine, Atypical antipsychotic (AB120019)

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Biochemicals

AB147474

Clozapine N-oxide, Metabolite of Clozapine (aqueous solution)

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Biochemicals

AB141704

Clozapine N-oxide, Metabolite of Clozapine

Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (AB141704)

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Assay Kits

AB150678

Oil Red O Stain Kit (Lipid Stain)

Histology - Oil Red O Stain Kit (Lipid Stain) (AB150678)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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제품 프로토콜

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Product promise

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