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AB120317

NNC 05-2090, GABA uptake inhibitor

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MW 451 Da, Purity >99%. GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.
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Chemical Structure - NNC 05-2090, GABA uptake inhibitor (AB120317)
  • Chemical Structure

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Chemical Structure - NNC 05-2090, GABA uptake inhibitor (AB120317)

2D chemical structure image of ab120317, NNC 05-2090, GABA uptake inhibitor

주요 정보

CAS 번호

184845-43-0

Purity

>99%

제형

Solid

form

Molecular weight

451 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>1</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

18782760

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

1-[3-(9H-Carbazol-9-YL)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

생물학적 정보

GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.

Canonical SMILES

COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl

InChi

InChI=1S/C27H30N2O2.ClH/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29;/h2-7,9-14,30H,8,15-20H2,1H3;1H

InChiKey

WDFXPKKFSNMGOO-UHFFFAOYSA-N

IUPAC Name

1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol;hydrochloride

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보완 제품

Biochemicals

AB120238

Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist

Chemical Structure - Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist (AB120238)

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Primary Antibodies

AB25025

FITC Anti-Ly6c antibody [HK1.4]

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Biochemicals

AB144596

SMER3, SCFMet30 ubiquitin E3 ligase inhibitor

Chemical Structure - SMER3, SCFMet30 ubiquitin E3 ligase inhibitor (AB144596)

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Biochemicals

AB120787

Medetomidine hydrochloride, alpha2 adrenoceptor agonist

Chemical Structure - Medetomidine hydrochloride, alpha2 adrenoceptor agonist (AB120787)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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