AB120078

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Be the first to review this product! 리뷰 제출

(14 제품이 사용된 논문 )

Norbinaltorphimine dihydrochloride/nor-Binaltorphimine(CAS:113158-34-2)(ab120078) is a potent and selective kappa opioid receptor antagonist. MW 734.7, Purity >98%.

- Available in different sizes to fit your experimental needs. Larger volume format available upon request

1 이미지

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

Chemical Structure

Lab

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

2D chemical structure image of ab120078, nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

주요 정보

CAS 번호

113158-34-2

Purity

>98%

제형

Solid

form

Molecular weight

734.7 Da

Molecular formula

C40H45Cl2N3O6

PubChem

11957626

Nature

Synthetic

Solubility

Soluble in water to 50 mM

생화학적 명칭

nor-Binaltorphimine dihydrochloride

생물학적 정보

Potent and selective κ opioid receptor antagonist

Canonical SMILES

C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

Isomeric SMILES

C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

InChi

InChI=1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChiKey

JOJPJLHRMGPDPV-LZQROVCBSA-N

IUPAC Name

(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol;dihydrochloride

style

left-column

style

left-column

제품 세부 정보

Check out our range of opioid antagonist biochemicals here

style

left-column

특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

-20°C

적절한 장기 보관 조건

-20°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

style

left-column

style

left-column

style

left-column

제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

style

left-column

제품이 사용된 논문 (14)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC nephrology 26:307 PubMed40596915

2025

Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia-reperfusion-induced acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroto Takeuchi,Satoshi Tatemichi,Yuji Okuhara

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 21:e00377 PubMed38777742

2024

A synthetic peptide exerts nontolerance-forming antihyperalgesic and antidepressant effects in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjiang Wu,Xiaofei Song,YanZhe Ji,Gang Chen,Long Zhao

Journal of molecular neuroscience : MN 74:3 PubMed38183534

2024

The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chi Xu,Jiayu Ye,Yanting Sun,Xiujian Sun,Jing-Gen Liu

Nature communications 14:7903 PubMed38036497

2023

The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jun Wang,Gui-Ying Zan,Cenglin Xu,Xue-Ping Li,Xuelian Shu,Song-Yu Yao,Xiao-Shan Xu,Xiaoyun Qiu,Yexiang Chen,Kai Jin,Qi-Xin Zhou,Jia-Yu Ye,Yi Wang,Lin Xu,Zhong Chen,Jing-Gen Liu

Molecules (Basel, Switzerland) 28: PubMed37836768

2023

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol.

Applications

Unspecified application

Species

Unspecified reactive species

Fumika Karaki,Taro Takamori,Koumei Kawakami,Sae Sakurai,Kyoko Hidaka,Kei Ishii,Tomoya Oki,Noriko Sato,Nao Atsumi,Karin Ashizawa,Ai Taguchi,Asuka Ura,Toko Naruse,Shigeto Hirayama,Miki Nonaka,Kanako Miyano,Yasuhito Uezono,Hideaki Fujii

Journal of leukocyte biology 112:1317-1328 PubMed36205434

2022

Morphine disrupts macrophage functions even during HIV infection.

Applications

Unspecified application

Species

Unspecified reactive species

John M Barbaro,Matias Jaureguiberry-Bravo,Simone Sidoli,Joan W Berman

Pain research & management 2022:4819910 PubMed35646201

2022

Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Huiying Huang,Xiaohui Bai,Kun Zhang,Jin Guo,Shaoyong Wu,Handong Ouyang

Neuroscience bulletin 38:403-416 PubMed35397112

2022

Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Fu-Jun Zhai,Song-Ping Han,Tian-Jia Song,Ran Huo,Xing-Yu Lan,Rong Zhang,Ji-Sheng Han

Communications biology 5:299 PubMed35365763

2022

Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Makino,Yuki Kamiyama,J B Brown,Toshiya Tanaka,Ryusuke Murakami,Yuki Teramoto,Takayuki Goto,Shusuke Akamatsu,Naoki Terada,Takahiro Inoue,Tatsuhiko Kodama,Osamu Ogawa,Takashi Kobayashi

Acta pharmacologica Sinica 43:1372-1382 PubMed34493813

2021

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan-Yuan Wei,Yan Ma,Song-Yu Yao,Ling-Hui Kong,Xiao Liu,Jing-Rui Chai,Jing Chen,Wei Li,Yu-Jun Wang,Li-Ming Shao,Jing-Gen Liu

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

Isomeric SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Primary Antibodies

Biochemicals

Primary Antibodies

Biochemicals

제품 세부 정보

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (14)

Product promise