AB120210

omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

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MW 5202 Da. Achieve your results faster with highly validated, pure and trusted compounds.

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Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

FuncS

PubMed

Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Many VGCC subtypes contribute to calcium signalling in ganglion cell bodies.

Summary of Ca²⁺ imaging results in RGC somata showing the following changes in paired pulse Ca²⁺ signal in response to drugs (applied during the second K⁺ pulse) compared to their control paired K⁺ pulses (K) : 10 μM nifedipine (29%±7%; p = 0.0003; n = 20), 100 μM verapamil (VPM; 39%±5%; p<0.0001; n = 17), 400 nM ω-agatoxin IVA (AGT; 35%±14%; p = 0.0364; n = 9), 3 μM ω-conotoxin-GVIA (CTX; 23%±10%; p = 0.0423; n = 15), 3 μM mibefradil (MIB; 21%±6%; p = 0.0011; n = 16) and 200 nM TTX (40%±9%; p = 0.0004; n = 14).

(From Figure 7C of Sargoy et al).

Sargoy et al PLoS One. 2014; 9(1): e84507. Reproduced under the Creative Commons license https://creativecommons.org/publicdomain/zero/1.0/

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Chemical Structure

Lab

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

2D chemical structure image of ab120210, omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

주요 정보

CAS 번호

145017-83-0

제형

Solid

form

Molecular weight

5202 Da

Molecular formula

C217H360N68O60S10

PubChem

56841669

Nature

Synthetic

Solubility

Soluble in water to 1mg/ml

생화학적 명칭

omega-Agatoxin IVA

Canonical SMILES

CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)

Isomeric SMILES

CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N3)[C@@H](C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N)C(=O)N[C@@H](CCCCN)C(=O)N9CCC[C@H]9C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)[C@@H](C)CC)CCSC)[C@@H](C)O)CC(=O)N

InChi

InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-348-100-146-202(333)283-171(114(14)24-4)209(340)277-152-106-354-350-102-148(274-192(323)143(88-156(225)290)269-210(341)172(117(17)287)278-164(298)98-244-179(310)135(67-81-346-19)262-207(338)170(113(13)23-3)281-195(326)145(99-286)270-200(152)331)198(329)260-134(64-66-166(301)302)189(320)272-150(199(330)264-137(52-32-38-74-223)211(342)284-79-43-57-154(284)204(335)261-132(56-42-78-237-217(232)233)187(318)265-140(85-110(9)10)194(325)280-169(112(12)22-2)208(339)263-136(68-82-347-20)190(321)259-133(63-65-165(299)300)178(309)243-95-160(294)251-138(83-108(5)6)180(311)245-96-161(295)252-139(84-109(7)8)191(322)248-116(16)213(344)345)104-352-353-105-151(276-205(336)155-58-44-80-285(155)212(343)173(118(18)288)279-163(297)92-239-157(291)91-240-182(313)142(87-120-90-238-124-47-26-25-45-122(120)124)267-186(317)130(258-197(147)328)50-30-36-72-221)201(332)275-149(196(327)256-126(54-40-76-235-215(228)229)177(308)242-93-158(292)249-125(53-39-75-234-214(226)227)176(307)241-97-162(296)253-146)103-351-355-107-153(203(334)282-168)273-188(319)131(51-31-37-73-222)257-184(315)129(49-29-35-71-220)255-175(306)123(224)46-27-33-69-218/h25-26,45,47,59-62,90,108-118,123,125-155,168-173,238,286-289H,21-24,27-44,46,48-58,63-89,91-107,218-224H2,1-20H3,(H2,225,290)(H,239,291)(H,240,313)(H,241,307)(H,242,308)(H,243,309)(H,244,310)(H,245,311)(H,246,312)(H,247,337)(H,248,322)(H,249,292)(H,250,293)(H,251,294)(H,252,295)(H,253,296)(H,254,305)(H,255,306)(H,256,327)(H,257,315)(H,258,328)(H,259,321)(H,260,329)(H,261,335)(H,262,338)(H,263,339)(H,264,330)(H,265,318)(H,266,324)(H,267,317)(H,268,316)(H,269,341)(H,270,331)(H,271,314)(H,272,320)(H,273,319)(H,274,323)(H,275,332)(H,276,336)(H,277,340)(H,278,298)(H,279,297)(H,280,325)(H,281,326)(H,282,334)(H,283,333)(H,299,300)(H,301,302)(H,303,304)(H,344,345)(H4,226,227,234)(H4,228,229,235)(H4,230,231,236)(H4,232,233,237)/t111-,112-,113-,114-,115-,116-,117+,118+,123-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,168-,169-,170-,171-,172-,173-/m0/s1

InChiKey

NVVFOMZVLALQKT-JYRRICCISA-N

IUPAC Name

(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(1R,1aS,4S,7R,10S,13S,16S,22S,25S,28R,31S,34R,39R,42S,48S,57S,60S,63R,66S,72S,75S,78S,81S,84S,87R,92R,95S)-87-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-60,78-bis(4-aminobutyl)-25-(2-amino-2-oxoethyl)-4,13,84-tris[(2S)-butan-2-yl]-1a,66,95-tris(3-carbamimidamidopropyl)-31-(2-carboxyethyl)-75-(carboxymethyl)-22,48-bis[(1R)-1-hydroxyethyl]-10-(hydroxymethyl)-72-[(4-hydroxyphenyl)methyl]-57-(1H-indol-3-ylmethyl)-81-methyl-16-(2-methylsulfanylethyl)-2,2a,5,5a,8,11,12a,14,17,20,23,26,29,32,41,47,50,53,56,59,62,65,68,71,74,77,80,83,86,93,96,99-dotriacontaoxo-8a,9a,14a,15a,36,37,89,90-octathia-a,3,3a,6,6a,9,11a,12,15,18,21,24,27,30,33,40,46,49,52,55,58,61,64,67,70,73,76,79,82,85,94,97-dotriacontazapentacyclo[61.43.4.47,28.239,92.042,46]hexadecahectane-34-carbonyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[2-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

-20°C

적절한 장기 보관 조건

-20°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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제품 프로토콜

Visit the General protocols
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제품이 사용된 논문 (8)

Recent publications for all applications. Explore the 전체 목록 and refine your search

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2023

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

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Nagendran Ramalingam,Shan-Xue Jin,Tim E Moors,Luis Fonseca-Ornelas,Kazuma Shimanaka,Shi Lei,Hugh P Cam,Aurelia Hays Watson,Lisa Brontesi,Lai Ding,Dinc Yasat Hacibaloglu,Haiyang Jiang,Se Joon Choi,Ellen Kanter,Lei Liu,Tim Bartels,Silke Nuber,David Sulzer,Eugene V Mosharov,Weisheng V Chen,Shaomin Li,Dennis J Selkoe,Ulf Dettmer

Frontiers in oncology 12:978755 PubMed36091107

2022

Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma.

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Sicheng Bian,Xialin Zhang,Leilei Lin,Lili Sun,Zhibo Guo,Jie Pan,Jiangxia Cui,Hanbing Yao,Jing Xu,Zhuanghui Hao,Yuzhu Wang,Liguo Tong,Xingpeng Bu,Desheng Kong,Nianjiao Liu,Yinghua Li

Molecular biology of the cell 27:3329-3341 PubMed27605709

2016

Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.

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Trine Lisberg Toft-Bertelsen,Iwona Ziomkiewicz,Sébastien Houy,Paulo S Pinheiro,Jakob B Sørensen

The Journal of neuroscience : the official journal of the Society for Neuroscience 36:7184-97 PubMed27383593

2016

M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina.

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Unspecified application

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Unspecified reactive species

Cameron L Prigge,Po-Ting Yeh,Nan-Fu Liou,Chi-Chan Lee,Shih-Feng You,Lei-Lei Liu,David S McNeill,Kylie S Chew,Samer Hattar,Shih-Kuo Chen,Dao-Qi Zhang

PloS one 9:e84507 PubMed24416240

2014

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons.

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Unspecified application

Species

Unspecified reactive species

Allison Sargoy,Xiaoping Sun,Steven Barnes,Nicholas C Brecha

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:18951-65 PubMed24285900

2013

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

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Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmann,Fanny Malhaire,Eric Chapuy,Youssef Aissouni,Monique Etienne,Emmanuel Bourinet,Francine Acher,Jean-Philippe Pin,Alain Eschalier,Cyril Goudet

PloS one 7:e32256 PubMed22389692

2012

Nitric oxide signalling augments neuronal voltage-gated L-type (Ca(v)1) and P/q-type (Ca(v)2.1) channels in the mouse medial nucleus of the trapezoid body.

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Adam J B Tozer,Ian D Forsythe,Joern R Steinert

Journal of psychopharmacology (Oxford, England) 26:56-70 PubMed21890595

2011

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation.

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Unspecified application

Species

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Meina Wang,Matthew N Hill,Longhua Zhang,Boris B Gorzalka,Cecilia J Hillard,Bradley E Alger

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omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

주요 정보

CAS 번호

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

Canonical SMILES

Isomeric SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Primary Antibodies

Biochemicals

Biochemicals

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

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보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (8)

Product promise