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AB144638

Phortress, Antitumor agent

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MW 459.4 Da, Purity >98%. Potent antitumor agent (IC50 values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.
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Chemical Structure - Phortress, Antitumor agent (AB144638)
  • Chemical Structure

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Chemical Structure - Phortress, Antitumor agent (AB144638)

2D chemical structure image of ab144638, Phortress, Antitumor agent

주요 정보

CAS 번호

328087-38-3

Purity

>98%

제형

Solid

form

Molecular weight

459.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>5</sub>Cl<sub>2</sub>FN<sub>4</sub>OS

PubChem

9804228

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

생화학적 명칭

CID 9804228

생물학적 정보

Potent antitumor agent (IC50 values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.

Canonical SMILES

CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)C(CCCCN)N.Cl.Cl

Isomeric SMILES

CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)[C@H](CCCCN)N.Cl.Cl

InChi

InChI=1S/C20H23FN4OS.2ClH/c1-12-10-13(20-25-17-11-14(21)6-8-18(17)27-20)5-7-16(12)24-19(26)15(23)4-2-3-9-22;;/h5-8,10-11,15H,2-4,9,22-23H2,1H3,(H,24,26);2*1H/t15-;;/m0../s1

InChiKey

QZSMNTOCJVVFEU-CKUXDGONSA-N

IUPAC Name

(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide;dihydrochloride

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보완 제품

Reagents, Controls & Accessories

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Biochemicals

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Biochemicals

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제품 세부 정보

Sold under license from CRT.
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

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Product promise

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