Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist
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(2 제품이 사용된 논문 )
MW 419.9 Da, Purity >99%. Peripheral α1 and α2 adrenoceptor antagonist. Orally active vasodilator. Also melatonin MT3 antagonist.
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1,8-cineole 2-exo-monooxygenase, ADA1D_HUMAN, ADRA1A, ADRA1L1, AI838772, AW493413, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Albendazole monooxygenase, Albendazole sulfoxidase, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase kappa, DNA repair and recombination protein RAD54-like, DNA replication inhibitor, DinB homolog 1 (E. coli), FLJ11090, GEMI_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, Glucocorticoid inducible P450, HLP, HR 54, IMD42, MGC104252, MGC112732, MGC126680, MGC129539, NF 25, NR1F3, Nifedipine oxidase, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, OTTHUMP00000039393, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, POLK_HUMAN, POLQ, Polymerase (DNA directed) kappa, Quinine 3-monooxygenase, RAD 54A, RAD 54L, RAD54 (S. cerevisiae) like, RAD54 homolog, RAD54 like, RAD54 like (S. cerevisiae), RAD54 like protein, RAD54_HUMAN, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RP24-311F12.2, RP3 369A17.3, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SCAN1, TOR, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, hHR 54, hRAD 54, polymerase, DNA, kappa
- Chemical Structure
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Chemical Structure - Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist (AB120238)
2D chemical structure image of ab120238, Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteins like alpha 1 adrenergic receptors initiate cellular responses by increasing intracellular calcium. They engage in vasoconstriction and cardiac contraction mechanisms. Cytochrome P450 3A4 contributes significantly to steroid metabolism and detoxification of exogenous substances. TDP1 interacts within a complex to repair DNA breaks caused by topoisomerase I inhibitors. Geminin regulates cell cycle by inhibiting DNA replication initiation. RAD54 acts in coordination with RAD51 in homologous recombination repair pathways. DNA Polymerase Kappa serves as a translesion synthesis polymerase maintaining DNA replication over lesions. ROR gamma oversees important immune response processes and differentiation of T helper cells.
Pathways
The functions of alpha 1 adrenergic receptors fall under adrenergic signaling and smooth muscle contraction pathways. They interact with other components such as beta adrenergic receptors influencing systemic vascular resistance. CYP3A4 plays a vital role in the metabolic degradation pathway of various pharmaceuticals and endobiotics. Pathways involving TDP1 relate to the repair via tyrosyl-DNA phosphodiesterase activity in response to DNA damage. Geminin influences the cell cycle by controlling the licensing of DNA replication. RAD54 participates within DNA repair pathways and collaborates with RAD52. DNA Polymerase Kappa engages in DNA damage tolerance pathways critical during cellular replication stress. ROR gamma drivers transcriptional networks in immune cell differentiation and function involving similar networks as ROR alpha.
제품이 사용된 논문 (2)
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Scientific reports 6:32835 PubMed27596381
2016
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Species
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Journal of neurochemistry 116:984-95 PubMed21143600
2011
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Species
Unspecified reactive species
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