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AB141252

Progesterone, Endogenous progesterone receptor agonist

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MW 314.5 Da, Purity >99%. Endogenous progesterone receptor agonist (EC50 = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.
2 이미지
Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)

ab16895 staining MDM2 in MCF7 cells treated with progesterone (ab141252), by ICC/IF. Decrease in MDM2 expression correlates with increased concentration of progesterone, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab141252 (progesterone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16895 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)
  • Chemical Structure

Lab

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)

2D chemical structure image of ab141252, Progesterone, Endogenous progesterone receptor agonist

주요 정보

Purity

>99%

제형

Solid

form

Molecular weight

314.5 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>2</sub>

PubChem

12303971

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

생화학적 명칭

17-Acetylandrosta-4-ene-3-one

생물학적 정보

Endogenous progesterone receptor agonist (EC50 = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.

Canonical SMILES

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric SMILES

CC(=O)C1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

InChi

InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17?,18-,19-,20-,21+/m0/s1

InChiKey

RJKFOVLPORLFTN-MWXAKFKLSA-N

IUPAC Name

(8S,9S,10R,13S,14S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

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보완 제품

Biochemicals

AB120657

17beta-Estradiol, Selective agonist of ER receptor

Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (AB120657)

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Biochemicals

AB144308

MTSSL, thiol-specific spin label

Chemical Structure - MTSSL, thiol-specific spin label (AB144308)

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Biochemicals

AB254448

Galunisertib (LY2157299), TGFB kinase antagonist

Chemical Structure - Galunisertib (LY2157299), TGFB kinase antagonist (AB254448)

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Primary Antibodies

AB183497

Anti-VSV-G tag antibody [EPR12997]

RabMAb|Recombinant|Lab Essentials

Western blot - Anti-VSV-G tag antibody [EPR12997] (AB183497)

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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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제품 프로토콜

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Product promise

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