AB120933

Purmorphamine, Smoothened receptor agonist

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(7 제품이 사용된 논문 )

MW 520.63 g/mol, Purity >98%. Smoothened (Smo) receptor agonist (EC₅₀ ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells. When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

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Chemical Structure - Purmorphamine, Smoothened receptor agonist (AB120933)

Chemical Structure

Lab

Chemical Structure - Purmorphamine, Smoothened receptor agonist (AB120933)

2D chemical structure image of ab120933, Purmorphamine, Smoothened receptor agonist

주요 정보

CAS 번호

483367-10-8

Purity

>98%

제형

Solid

form

Molecular weight

520.63 g/mol

Molecular formula

C31H32N6O2

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

생물학적 정보

Smoothened (Smo) receptor agonist (EC₅₀ ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Canonical SMILES

O1CCN(CC1)C1CCC(CC1)NC1NC(OC2CCCC3CCCCC23)NC2C1NCN2C1CCCCC1

IUPAC Name

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

-20°C

적절한 장기 보관 조건

-20°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (7)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature protocols 18:3918-3973 PubMed37985878

2023

Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain.

Applications

Unspecified application

Species

Unspecified reactive species

Mara Zilocchi,Matineh Rahmatbakhsh,Mohamed Taha Moutaoufik,Kirsten Broderick,Alla Gagarinova,Matthew Jessulat,Sadhna Phanse,Hiroyuki Aoki,Khaled A Aly,Mohan Babu

EMBO reports 24:e55571 PubMed36744302

2023

Ubiquitylation of BBSome is required for ciliary assembly and signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Francesco Chiuso,Rossella Delle Donne,Giuliana Giamundo,Laura Rinaldi,Domenica Borzacchiello,Federica Moraca,Daniela Intartaglia,Rosa Iannucci,Emanuela Senatore,Luca Lignitto,Corrado Garbi,Paolo Conflitti,Bruno Catalanotti,Ivan Conte,Antonio Feliciello

Communications biology 4:1071 PubMed34552196

2021

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren Malave,Dustin R Zuelke,Santiago Uribe-Cano,Lev Starikov,Heike Rebholz,Eitan Friedman,Chuan Qin,Qin Li,Erwan Bezard,Andreas H Kottmann

The EMBO journal 40:e106503 PubMed33934390

2021

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

Applications

Unspecified application

Species

Unspecified reactive species

Emanuela Senatore,Francesco Chiuso,Laura Rinaldi,Daniela Intartaglia,Rossella Delle Donne,Emilia Pedone,Bruno Catalanotti,Luciano Pirone,Bianca Fiorillo,Federica Moraca,Giuliana Giamundo,Giovanni Scala,Andrea Raffeiner,Omar Torres-Quesada,Eduard Stefan,Marcel Kwiatkowski,Alienke van Pijkeren,Manuela Morleo,Brunella Franco,Corrado Garbi,Ivan Conte,Antonio Feliciello

Nature communications 11:414 PubMed31964872

2020

Structural insight into small molecule action on Frizzleds.

Applications

Unspecified application

Species

Unspecified reactive species

Paweł Kozielewicz,Ainoleena Turku,Carl-Fredrik Bowin,Julian Petersen,Jana Valnohova,Maria Consuelo Alonso Cañizal,Yuki Ono,Asuka Inoue,Carsten Hoffmann,Gunnar Schulte

Molecular therapy : the journal of the American Society of Gene Therapy 28:452-465 PubMed31866117

2019

Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Se-Ra Park,Soo-Rim Kim,Chan Hum Park,Soyi Lim,Seung Yeon Ha,In-Sun Hong,Hwa-Yong Lee

Molecular therapy : the journal of the American So 27:1286-1298 PubMed31080015

2019

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2.

Applications

Unspecified application

Species

Unspecified reactive species

Ara Cho,Se-Ra Park,Soo-Rim Kim,Seungyoon Nam,Soyi Lim,Chan Hum Park,Hwa-Yong Lee,In-Sun Hong

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Purmorphamine, Smoothened receptor agonist

Chemical Structure - Purmorphamine, Smoothened receptor agonist (AB120933)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

Nature

Solubility

생물학적 정보

Canonical SMILES

IUPAC Name

보완 제품

Biochemicals

Biochemicals

Biochemicals

Primary Antibodies

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (7)

Product promise