AB120117

QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

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MW 343.3 Da, Purity >99%. A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.

대체 명칭 보기

ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, Acetylcholine receptor muscarinic 5, CHKM5MR, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, HM 4, HM 5, M4, M5R, MGC41838, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, m5

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Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

Chemical Structure

Lab

Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

2D chemical structure image of ab120117, QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

주요 정보

CAS 번호

21306-56-9

Purity

>99%

제형

Solid

form

Molecular weight

343.3 Da

Molecular formula

C16H27BrN2O

PubChem

9884487

Nature

Synthetic

생화학적 명칭

Lidocaine N-ethyl bromide

생물학적 정보

A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical SMILES

CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]

InChi

InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChiKey

DLHMKHREUTXMCH-UHFFFAOYSA-N

IUPAC Name

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromide

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Muscarinic acetylcholine receptors M4 (CHRM4) and M5 (CHRM5) are types of G protein-coupled receptors (GPCRs) that interact with the neurotransmitter acetylcholine. CHRM4 has a molecular mass around 49 kDa while CHRM5's mass is approximately 53 kDa. CHRM4 is expressed in areas like the cortex hippocampus and striatum while CHRM5 is found in regions like the basal forebrain and the thalamus. These receptors mediate different physiological responses through the modulation of intracellular signaling pathways.

Biological function summary

Muscarinic acetylcholine receptors are critical in regulating functions such as cognitive processing motor control and autonomic nervous system actions. They do not operate as part of a multi-protein complex but engage in signaling mechanisms after neurotransmitter binding. Both receptor types contribute to neural circuitry by activating phosphoinositide breakdown and modulating cyclic AMP levels.

Pathways

Muscarinic acetylcholine receptors participate in the cholinergic signaling pathway. This pathway is essential for neurotransmission in the central and peripheral nervous systems. Interaction with G proteins particularly Gi/o for CHRM4 and Gq/11 for CHRM5 allows these receptors to influence downstream effectors like phospholipase C. Other proteins related to this pathway include the nicotinic acetylcholine receptors that also bind acetylcholine to propagate neural signals.

Muscarinic acetylcholine receptors are linked to conditions like schizophrenia and Alzheimer's disease. CHRM4 appears connected to schizophrenia likely due to its role in modulating dopaminergic and glutamatergic neurotransmission. CHRM5 through its signaling pathways relates to Alzheimer’s impacting cognitive functions. Both receptors maintain interactions with proteins like the NMDA receptor in the context of these disorders influencing their pathophysiological roles.

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제품 프로토콜

Visit the General protocols
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제품이 사용된 논문 (14)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:3949-3969 PubMed37037606

2023

Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice.

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Unspecified reactive species

Ke Xi,Si-Qing Cai,Hui-Fang Yan,Yue Tian,Jie Cai,Xiao-Mei Yang,Jing-Min Wang,Guo-Gang Xing

Cell 172:1108-1121.e15 PubMed29474910

2018

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue.

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Jan Tønnesen,V V G Krishna Inavalli,U Valentin Nägerl

Neuron 95:1306-1318.e5 PubMed28910619

2017

Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.

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Hong-Yuan Chu,Eileen L McIver,Ryan F Kovaleski,Jeremy F Atherton,Mark D Bevan

Cerebral cortex (New York, N.Y. : 1991) 26:2715-27 PubMed26045570

2015

Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways.

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Tsan-Ting Hsu,Cheng-Ta Lee,Ming-Hong Tai,Cheng-Chang Lien

Nature neuroscience 18:674-82 PubMed25821912

2015

GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.

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Marzieh Zonouzi,Joseph Scafidi,Peijun Li,Brian McEllin,Jorge Edwards,Jeffrey L Dupree,Lloyd Harvey,Dandan Sun,Christian A Hübner,Stuart G Cull-Candy,Mark Farrant,Vittorio Gallo

Proceedings of the National Academy of Sciences of 110:15800-5 PubMed24019494

2013

Presynaptic gating of excitation in the dorsal raphe nucleus by GABA.

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Mariano Soiza-Reilly,Wayne B Anderson,Christopher W Vaughan,Kathryn G Commons

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:5486-98 PubMed23536064

2013

Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.

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Giulia Quattrocolo,Gianmaria Maccaferri

Journal of neurophysiology 109:2712-9 PubMed23515792

2013

Serotonergic modulation of neuronal activity in rat midbrain periaqueductal gray.

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Hyo-Jin Jeong,Karen Lam,Vanessa A Mitchell,Christopher W Vaughan

Journal of neurophysiology 109:1704-12 PubMed23303863

2013

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.

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Michelino Puopolo,Alexander M Binshtok,Gui-Lan Yao,Seog Bae Oh,Clifford J Woolf,Bruce P Bean

BMC neuroscience 13:14 PubMed22276909

2012

Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.

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Species

Unspecified reactive species

Ilse Riebe,Eric Hanse

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QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (AB120117)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

생화학적 명칭

생물학적 정보

Canonical SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Biochemicals

Biochemicals

Biochemicals

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

추가 정보

Biological function summary

Pathways

제품 프로토콜

제품이 사용된 논문 (14)

Product promise