MW 287.3 Da, Purity >99%. Indoloquinazoline alkaloid derived from Evodia rutaecarpa. Various pharmacological actions in vitro and in vivo; anti-inflammatory, antinociceptive, vasorelaxant, antiplatelet aggregation. Pharmacologically active following oral administration.
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2410064E05Rik, AHH, AI195561, ALBU_HUMAN, ANP-A, ANPRA_HUMAN, AR JP, ARNT-interacting protein, Albumin (32 AA), Albumin (AA 34), Aryl hydrocarbon hydroxylase, Atrial natriuretic peptide A type receptor, Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor A, Atrial natriuretic peptide receptor type A, Atrionatriuretic peptide receptor A, BCD541, Basic-helix-loop-helix-PAS protein MOP1, C-mpl ligand, CP 12, CP11, CP1A1_HUMAN, CP1A2_HUMAN, CP1B, CP1B1_HUMAN, CYP 1, CYP1A2, CYPIA1, CYPIA2, CYPIB1, Capsaicin receptor, Class E basic helix-loop-helix protein 78, Component of gems 1, Cyclooxygenase, Cyclooxygenase 2b, Cyclooxygenase 3, included, Cyclooxygenase-1, Cyclooxygenase-2, Cytochrome P(3)450, Cytochrome P1 450 dioxin inducible, Cytochrome P1-450, Cytochrome P450 1A1, Cytochrome P450 1A2, Cytochrome P450 1B1, Cytochrome P450 4, Cytochrome P450 family 1 polypeptide 2, Cytochrome P450 family 1 subfamily A polypeptide 1, Cytochrome P450 family 1 subfamily A polypeptide 2, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 form 6, Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2, Cytochrome P450-C, Cytochrome P450-P1, Cytochrome P450-P3, DKFZp434K0220, DKFZp779N1935, Dioxin inducable P3 450, DmRab9, E3 ubiquitin ligase, E3 ubiquitin-protein ligase parkin, EC 1.14.99.1, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FRA6E, GC-A, GIG20, GIG42, GLC3A, GRIPGHS, GUCY2A, Gemin-1, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, Glucocorticoid-regulated inflammatory cyclooxygenase, Guanylate cyclase, Guanylate cyclase A, HIF-1, HIF-1-alpha, HIF-alpha, HIF1A_HUMAN, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor), Hypoxia-inducible factor 1-alpha, LPRS 2, MGDF, MKCSF, MOP 1, MPL ligand, MPLLG, Macrophage activation-associated marker protein P71/73, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, Megakaryocyte stimulating factor, Member of PAS protein 1, Member of PAS superfamily 1, Member of the PAS Superfamily 1, Microsomal monooxygenase, Myeloproliferative leukemia virus oncogene ligand, NPC, NPC1_HUMAN, NPR-A, NPR1, NR3B1, Natriuretic Peptide Receptor A, Natriuretic peptide A type receptor, Natriuretic peptide receptor A/guanylate cyclase A, Niemann Pick C1 protein precursor, Niemann Pick disease, type C1, Niemann-Pick C1 protein, Nuclear receptor subfamily 3 group B member 1, OTRPC1, OTTHUMP00000033524, OTTHUMP00000125198, OTTHUMP00000220436, OTTHUMP00000220438, OTTHUMP00000220439, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, Osm-9-like TRP channel 1, P(3)450, P1 450, P3 450, P450 4, P450 C, P450 P1, P450 P3, P450 form 4, P450 form 6, P450(PA), P4501B1, P450DX, PARK 2, PAS domain-containing protein 8, PASD 8, PCOX1, PDJ, PES-2, PGG/HS, PGH synthase 1, PGH synthase 2, PGH1_HUMAN, PGH2_HUMAN, PGHS-1, PGHS-2, PHS 1, PHS 2, PHS II, PRKN 2, PRKN2_HUMAN, PRO0883, PRO0903, PRO1341, PRO1708, PRO2044, PRO2619, PRO2675, PTGHS, PTGS1, PTGS2, Parkin 2, Parkinson disease (autosomal recessive juvenile) 2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, Parkinson disease protein 2, Parkinson juvenile disease protein 2, Parkinson protein 2 E3 ubiquitin protein ligase, Parkinson protein 2, E3 ubiquitin protein ligase (parkin), Partial COX1 proteins, included, Prostaglandin G/H synthase, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 1, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 2, RAB9 member RAS oncogene family, RAB9A member RAS oncogene family, RAB9A_HUMAN, RAS ASSOCIATED PROTEIN RAB9, Rab 9, Ras-related protein Rab-9A, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMN1, SMN2, SMNT, SMN_HUMAN, Sid6061p, Sid99, Steroid hormone receptor ERR1, Survival motor neuron protein, Survival of motor neuron 1, telomeric, T-BCD541, THCYT1, TIS10, TIS10 protein, TRPV1_HUMAN, Thrombopoietin, Thrombopoietin nirs variant 1, Transient receptor potential cation channel subfamily V member 1, UNQ696/PRO1341, Ubiquitin E3 ligase PRKN, VR 1, Vanilloid receptor 1, Vanilloid receptor subtype 1, Xenobiotic monooxygenase, bHLHe78, cell growth inhibiting protein 42, estrogen receptor related receptor alpha, fj02a10, flavoprotein-linked monooxygenase, growth-inhibiting protein 20, hCox 2, hERR1, hifla, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), ptgs2a, unp1239, wu:fj02a10
- Chemical Structure
Lab
Chemical Structure - Rutaecarpine, Indoloquinazoline alkaloid (AB141145)
2D chemical structure image of ab141145, Rutaecarpine, Indoloquinazoline alkaloid
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Each of these proteins regulates specific systems. COX2 mediates inflammatory responses making it part of the prostaglandin biosynthesis pathway. TRPV1 being a part of the ion channel family modulates pain perception and thermoregulation. Parkin plays a significant role in protein degradation via the ubiquitin-proteasome system critical in maintaining cellular homeostasis. TPO or Thyroid Peroxidase supports thyroid hormone production essential for metabolic regulation. Proteins like NPC1 aid lipid transport and homeostasis being components of the lysosomal network.
Pathways
COX2 functions significantly in the arachidonic acid metabolism pathway. Its interaction with proteins such as COX1 is vital for synthesizing prostaglandins enhancing therapeutic targets for anti-inflammatory drugs. Meanwhile Parkin engages in mitochondrial quality control pathways interacting with other proteins like PINK1 in regulating apoptotic processes. These interactions illustrate the interconnected nature of these proteins within cellular signaling networks.
Product promise
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