AB142160

SAG (Smo agonist), Smoothened agonist

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(13 제품이 사용된 논문 )

MW 490.1 Da, Purity >98%. Cell-permeable, selective, potent Smoothened agonist (EC₅₀ = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active in vitro and in vivo.

대체 명칭 보기

FZD11, Frizzled family member 11, GX, Gx protein, Protein Gx, SMOH, SMO_HUMAN, Smoothened frizzled family receptor, Smoothened homolog, Smoothened homolog (Drosophila), Smoothened homolog precursor (SMO) (Gx protein), Smoothened seven transmembrane spanning receptor

1 이미지

Chemical Structure - SAG (Smo agonist), Smoothened agonist (AB142160)

Chemical Structure

Lab

Chemical Structure - SAG (Smo agonist), Smoothened agonist (AB142160)

2D chemical structure image of ab142160, SAG (Smo agonist), Smoothened agonist

주요 정보

CAS 번호

364590-63-6

Purity

>98%

제형

Solid

form

Molecular weight

490.1 Da

Molecular formula

C28H28ClN3OS

PubChem

5284330

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

생화학적 명칭

Smoothened agonist

생물학적 정보

Cell-permeable, selective, potent Smoothened agonist (EC₅₀ = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active in vitro and in vivo.

Canonical SMILES

CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl

InChi

InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3

InChiKey

VFSUUTYAEQOIMW-UHFFFAOYSA-N

IUPAC Name

3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

-20°C

적절한 장기 보관 조건

-20°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Smoothened (SMO) is a protein that plays a vital role in the Hedgehog signaling pathway. It is also known by other names such as SMOH and Smoothened homolog. This protein has a molecular mass of approximately 86 kDa. Smoothened is expressed in a variety of tissues including the brain lungs and kidneys. It functions as a transmembrane protein with seven helices which transmits signals across the cell membrane.

Biological function summary

Smoothened influences cellular processes by participating in the Hedgehog signaling pathway. It operates as part of a complex with the Patched (PTCH) receptor. When the Hedgehog ligand binds to PTCH Smoothened becomes activated. This activation leads to changes in gene expression that control cell growth and differentiation. Smoothened is critical in embryonic development tissue regeneration and stem cell maintenance.

Pathways

Smoothened interacts with essential components of the Hedgehog signaling pathway. This pathway includes proteins like PTCH and Gli transcription factors. Smoothened activation triggers the release of these Gli proteins from inhibitory complexes which then migrate to the nucleus to modulate the transcription of target genes. The Hedgehog pathway is important in regulating developmental processes and cellular responses.

Smoothened has connections to various forms of cancer including basal cell carcinoma and medulloblastoma. Abnormal activation or mutations in Smoothened can lead to unchecked cell proliferation. Smoothened also shows relevance in the development of gliomas. Drugs like 'anti smo' or 'glasdegib' act as Smoothened antagonists aiming to inhibit its function in these diseases by targeting the Hedgehog signaling pathway.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (13)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:2127 PubMed39820844

2025

Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia.

Applications

Unspecified application

Species

Unspecified reactive species

Jae Hee Jun,Hwayeon Cha,Je Yeong Ko,Ho-Shik Kim,Kyung Hyun Yoo,Jong Hoon Park

Cellular and molecular life sciences : CMLS 81:75 PubMed38315424

2024

LRP10 and α-synuclein transmission in Lewy body diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Carreras Mascaro,Martyna M Grochowska,Valerie Boumeester,Natasja F J Dits,Ece Naz Bilgiҫ,Guido J Breedveld,Leonie Vergouw,Frank Jan de Jong,Martin E van Royen,Vincenzo Bonifati,Wim Mandemakers

Cellular and molecular life sciences : CMLS 81:70 PubMed38294527

2024

Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway.

Applications

Unspecified application

Species

Unspecified reactive species

N Kokkorakis,K Douka,A Nalmpanti,P K Politis,L Zagoraiou,R Matsas,M Gaitanou

Nature communications 15:365 PubMed38191484

2024

Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Accogli,Saurabh Shakya,Taewoo Yang,Christine Insinna,Soo Yeon Kim,David Bell,Kirill R Butov,Mariasavina Severino,Marcello Niceta,Marcello Scala,Hyun Sik Lee,Taekyeong Yoo,Jimmy Stauffer,Huijie Zhao,Chiara Fiorillo,Marina Pedemonte,Maria C Diana,Simona Baldassari,Viktoria Zakharova,Anna Shcherbina,Yulia Rodina,Christina Fagerberg,Laura Sønderberg Roos,Jolanta Wierzba,Artur Dobosz,Amanda Gerard,Lorraine Potocki,Jill A Rosenfeld,Seema R Lalani,Tiana M Scott,Daryl Scott,Mahshid S Azamian,Raymond Louie,Hannah W Moore,Neena L Champaigne,Grace Hollingsworth,Annalaura Torella,Vincenzo Nigro,Rafal Ploski,Vincenzo Salpietro,Federico Zara,Simone Pizzi,Giovanni Chillemi,Marzia Ognibene,Erin Cooney,Jenny Do,Anders Linnemann,Martin J Larsen,Suzanne Specht,Kylie J Walters,Hee-Jung Choi,Murim Choi,Marco Tartaglia,Phillippe Youkharibache,Jong-Hee Chae,Valeria Capra,Sung-Gyoo Park,Christopher J Westlake

Advanced science (Weinheim, Baden-Wurttemberg, Germany) :e2202632 PubMed36373718

2022

Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Daishi Yamakawa,Junya Tsuboi,Kousuke Kasahara,Chise Matsuda,Yuhei Nishimura,Tatsuya Kodama,Naoyuki Katayama,Masatoshi Watanabe,Masaki Inagaki

Communications biology 4:1066 PubMed34518642

2021

FBW7 couples structural integrity with functional output of primary cilia.

Applications

Unspecified application

Species

Unspecified reactive species

Eleni Petsouki,Vasileios Gerakopoulos,Nicholas Szeto,Wenhan Chang,Mary Beth Humphrey,Leonidas Tsiokas

The Journal of cell biology 220: PubMed33856408

2021

Time-resolved proteomics profiling of the ciliary Hedgehog response.

Applications

Unspecified application

Species

Unspecified reactive species

Elena A May,Marian Kalocsay,Inès Galtier D'Auriac,Patrick S Schuster,Steven P Gygi,Maxence V Nachury,David U Mick

The Journal of biological chemistry 295:14723-14736 PubMed32820051

2020

Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Yamazoe,Tomoaki Nagai,Shinya Umeda,Yuko Sugaya,Kensaku Mizuno

BMB reports 52:619-624 PubMed31619317

2019

Deficiency of calpain-6 inhibits primary ciliogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Hye Kim,Do Yeon Kim,Sumin Oh,Je Yeong Ko,Gyuyeong Rah,Kyung Hyun Yoo,Jong Hoon Park

Developmental biology 455:369-381 PubMed31301300

2019

NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Steven Tessier,Vedavathi Madhu,Zariel I Johnson,Irving M Shapiro,Makarand V Risbud

제품이 사용된 논문 모두 보기

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SAG (Smo agonist), Smoothened agonist

Chemical Structure - SAG (Smo agonist), Smoothened agonist (AB142160)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Primary Antibodies

Primary Antibodies

Reagents, Controls & Accessories

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

추가 정보

Biological function summary

Pathways

제품 프로토콜

제품이 사용된 논문 (13)

Product promise