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AB146590

SB431542 (DMSO solution), ALK inhibitor

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(2 제품이 사용된 논문 )

SB431542 (CAS: 301836-41-9) (ab146590) is a ALK inhibitor in DMSO solution. Potent and selective inhibitor of Activin Like Kinase (ALK). Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. TGF-β receptor kinase inhibitor (TRKI). MW 384.4.

- Larger volume format available upon request

대체 명칭 보기

AAT 5, ACTR-IB, ACTR-IC, ACV1B_HUMAN, ACV1C_HUMAN, ACVR 1B, ACVRLK 4, ACVRLK7, ALK-4, ALK-5, ALK-7, Activin A receptor type 1B, Activin A receptor type II like kinase, Activin A receptor type II like kinase 4, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin A receptor, type IC, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor type 1C precursor, Activin receptor type IB, Activin receptor type IC, Activin receptor type-1B, Activin receptor type-1C, Activin receptor-like kinase 4, Activin receptor-like kinase 5, Activin receptor-like kinase 7, Acvr1c, LDS1A, LDS2A, MSSE, SKR 2, SKR 4, Serine(threonine) protein kinase receptor R2, Serine/threonine-protein kinase receptor R2, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TbetaR-I, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor-beta receptor type I, activin A receptor type II-like protein kinase of 53kD

1 이미지
Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (AB146590)
  • Chemical Structure

Lab

Chemical Structure - SB431542 (DMSO solution), ALK inhibitor (AB146590)

2D chemical structure image of ab146590, SB431542 (DMSO solution), ALK inhibitor

주요 정보

CAS 번호

301836-41-9

Purity

>99%

제형

Liquid

form

Molecular weight

384.4 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>6</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

4521392

Nature

Synthetic

생화학적 명칭

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

생물학적 정보

Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Canonical SMILES

C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

InChi

InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

InChiKey

FHYUGAJXYORMHI-UHFFFAOYSA-N

IUPAC Name

4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

10 mM

제품 세부 정보

Check out our range of ALK inhibitor biochemicals here

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

제품 프로토콜

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 29:2702-2717.e7 PubMed31775039

2019

Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy J Kelly,Anneke Brümmer,Nima Hooshdaran,Mito Tariveranmoshabad,Jesse R Zamudio

Developmental cell 50:462-477.e5 PubMed31204172

2019

Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Mattias Malaguti,Rosa Portero Migueles,Guillaume Blin,Chia-Yi Lin,Sally Lowell
제품이 사용된 논문 모두 보기

Product promise

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