MW 440.4 Da, Purity >98%. Potent, selective sphingosine-1-phosphate (S1P1) agonist (EC50 = 13 nM). Does not activate S1P2, S1P3, S1P4 or S1P5 receptors. Cell-permeable and active *in vivo*.
대체 명칭 보기
CD363, CHEDG 1, D1S3362, ECGF 1, EDG 1, EDG8 S1P receptor, Endothelial Differentiation Gene 8, Endothelial differentiation G-protein coupled receptor 1, Endothelial differentiation G-protein-coupled receptor 8, Endothelial differentiation sphingolipid G protein coupled receptor 1, Endothelial differentiation sphingolipid G protein coupled receptor 8, FLJ58121, G protein coupled sphingolipid receptor, S1P receptor 1, S1P receptor 5, S1P receptor Edg-1, S1P receptor Edg-8, S1P(1) receptor, S1P1, S1P5, S1PR1_HUMAN, S1PR5_HUMAN, SPPR 1, SPPR 2, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor 5, Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor Edg-8, Sphingosine 1phosphate receptor type 1 S1P1, g protein-coupled receptor edg-1, sphingolipid g-protein-coupled receptor 1
- Chemical Structure
Lab
Chemical Structure - SEW 2871, S1P1 agonist (AB120983)
2D chemical structure image of ab120983, SEW 2871, S1P1 agonist
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
S1P1 regulates critical processes such as vascular homeostasis immune cell trafficking and endothelial barrier integrity. Importantly it forms part of a multi-subunit complex that includes other proteins like G-proteins. Upon activation by S1P the receptor can lead to cytoskeletal rearrangements and changes in cell morphology. S1P1’s function is linked closely with immune system modulation influencing lymphocyte circulation and migration.
Pathways
S1P1 participates actively in the sphingolipid signaling pathway and the PI3K/AKT pathway. This receptor interacts with molecules like Rac and RhoA which are essential for maintaining endothelial barrier function. Through these pathways S1P1 influences processes such as cell migration and proliferation making it important for maintaining vascular system dynamics. Its relationship with PI3K leads to the activation of downstream effectors necessary for cell survival and growth.
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Nature communications 8:2210 PubMed29263363
2017
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