AB120642

SQ 22536, Non-competitive adenylyl cyclase inhibitor

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(6 제품이 사용된 논문 )

MW 205.22 Da, Purity >99%. Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC₅₀ values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca²⁺ signalling in rat carotid bodies in vitro.

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Chemical Structure - SQ 22536, Non-competitive adenylyl cyclase inhibitor (AB120642)

Chemical Structure

Lab

Chemical Structure - SQ 22536, Non-competitive adenylyl cyclase inhibitor (AB120642)

2D chemical structure image of ab120642, SQ 22536, Non-competitive adenylyl cyclase inhibitor

주요 정보

CAS 번호

17318-31-9

Purity

>99%

제형

Solid

form

Molecular weight

205.22 Da

Molecular formula

C9H11N5O

PubChem

5270

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

생화학적 명칭

9-(Tetrahydrofuran-2-yl)-9h-purin-6-amine

생물학적 정보

Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC₅₀ values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca²⁺ signalling in rat carotid bodies in vitro.

Canonical SMILES

C1CC(OC1)N2C=NC3=C(N=CN=C32)N

InChi

InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)

InChiKey

UKHMZCMKHPHFOT-UHFFFAOYSA-N

IUPAC Name

9-(oxolan-2-yl)purin-6-amine

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제품 세부 정보

This compound appears to be unstable in strongly acidic solutions. We therefore recommend avoiding exposure to low pH.

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 15:9887 PubMed39543166

2024

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Cells 11: PubMed36359914

2022

Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC.

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Konstantin Kulebyakin,Pyotr Tyurin-Kuzmin,Leila Sozaeva,Nikita Voloshin,Mikhail Nikolaev,Vadim Chechekhin,Maxim Vigovskiy,Veronika Sysoeva,Elizaveta Korchagina,Daria Naida,Maria Vorontsova

Bone 135:115305 PubMed32126313

2020

Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.

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Subhashis Pal,Mamunur Rashid,Sandeep Kumar Singh,Konica Porwal,Priya Singh,Riyazuddin Mohamed,Jiaur R Gayen,Muhammad Wahajuddin,Naibedya Chattopadhyay

Frontiers in physiology 9:456 PubMed29867524

2018

Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer.

Applications

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Lea Weber,Wolfgang A Schulz,Stathis Philippou,Josephine Eckardt,Burkhard Ubrig,Michéle J Hoffmann,Andrea Tannapfel,Benjamin Kalbe,Günter Gisselmann,Hanns Hatt

Lipids in health and disease 15:213 PubMed27938411

2016

Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways.

Applications

Unspecified application

Species

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Hideo Ohira,Wao Tsutsui,Rie Mamoto,Sayaka Yamaguchi,Masako Nishida,Miki Ito,Yoshio Fujioka

Scientific reports 6:32835 PubMed27596381

2016

Activation of β-adrenergic receptors is required for elevated α1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Pyotr A Tyurin-Kuzmin,Julia I Fadeeva,Margarita A Kanareikina,Natalia I Kalinina,Veronika Yu Sysoeva,Daniyar T Dyikanov,Dmitriy V Stambolsky,Vsevolod A Tkachuk

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

SQ 22536, Non-competitive adenylyl cyclase inhibitor

Chemical Structure - SQ 22536, Non-competitive adenylyl cyclase inhibitor (AB120642)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Proteins & Peptides

Assay Kits

Assay Kits

Assay Kits

제품 세부 정보

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (6)

Product promise