Staurosporine (DMSO solution), protein kinase inhibitor
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(7 제품이 사용된 논문 )
Potent, cell-permeable, broad spectrum inhibitor of protein kinases. Kinases inhibited include: protein kinase C (PKC)(IC50 = 3 nM), cAMP-dependent protein kinase (IC50 = 8 nM) and p60v-src (IC50 = 6 nM). MW 466.5.
- Potent inhibitor of phospholipid- and calcium-dependent protein kinase
대체 명칭 보기
ASV, AW259666, Avian sarcoma virus, C SRC, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CTCL tumor antigen se20 9, CVID9, D14Ertd420e, EC 2.7.10.2, KPCA_HUMAN, KPCB_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCT_HUMAN, Kinase PKC delta, LOSK, May-01, MGC125656, MGC125657, MGC126514, MGC141919, MGC49908, MGC57564, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OTTHUMP00000043364, OTTHUMP00000043365, OTTHUMP00000067291, OTTHUMP00000174476, OTTHUMP00000174477, Oncogene SRC, PCKd, PKC 0, PKC 2, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC-A, PKC-B, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCT, PRKCZ, Pkcea, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, Protooncogene SRC Rous sarcoma, SCA 14, SNF1 sucrose nonfermenting like kinase, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, STE20 like serine/threonine-protein kinase, STE20 related kinase, STK-2, Serine/threonine protein kinase 2, Tyrosine kinase pp60c src, Tyrosine protein kinase PRKCD, Tyrosine protein kinase SRC 1, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), nPKC-delta, nPKC-epsilon, nPKC-theta, p60-Src, p60c-src, pp60c-src, se20 9, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian
- Chemical Structure
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Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (AB146588)
2D chemical structure image of ab146588, Staurosporine (DMSO solution), protein kinase inhibitor
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Need more advice on solubility, usage and handling? Please visit our our product support page for more details.
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Pathways
Several PKC isoforms engage critical cell signaling pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. In these pathways PKCs modulate various downstream effectors coordinating signals that influence gene expression and cell survival. PKC delta has significant associations with the MAPK cascade while PKC theta interacts closely with PI3K. These interactions are necessary for linking external signals to intracellular responses thereby acting as converging points for signaling pathways impacting multiple cellular functions.
Biological function summary
PKC isoforms regulate cellular functions like proliferation differentiation and apoptosis. These proteins are part of larger signaling complexes participating in dynamic equilibrium states that determine cellular fate. For example PKC epsilon often interacts within complexes modulating oncogenic pathways while PKC beta 2 plays roles in immune response modulation. The distinct expression patterns and interactions of these isoforms enable them to assume specific biological roles in different tissues.
제품이 사용된 논문 (7)
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The Journal of general virology 106: PubMed39928567
2025
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Aging 15:14172-14191 PubMed38095632
2023
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NPJ systems biology and applications 8:46 PubMed36443335
2022
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NAR genomics and bioinformatics 4:lqac065 PubMed36110898
2022
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Journal of cell science 135: PubMed35274124
2022
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Cell reports 26:3323-3335.e4 PubMed30893604
2019
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PloS one 13:e0206801 PubMed30395621
2018
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