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AB146588

Staurosporine (DMSO solution), protein kinase inhibitor

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(7 제품이 사용된 논문 )

Potent, cell-permeable, broad spectrum inhibitor of protein kinases. Kinases inhibited include: protein kinase C (PKC)(IC50 = 3 nM), cAMP-dependent protein kinase (IC50 = 8 nM) and p60v-src (IC50 = 6 nM). MW 466.5.

- Potent inhibitor of phospholipid- and calcium-dependent protein kinase

대체 명칭 보기

ASV, AW259666, Avian sarcoma virus, C SRC, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CTCL tumor antigen se20 9, CVID9, D14Ertd420e, EC 2.7.10.2, KPCA_HUMAN, KPCB_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCT_HUMAN, Kinase PKC delta, LOSK, May-01, MGC125656, MGC125657, MGC126514, MGC141919, MGC49908, MGC57564, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OTTHUMP00000043364, OTTHUMP00000043365, OTTHUMP00000067291, OTTHUMP00000174476, OTTHUMP00000174477, Oncogene SRC, PCKd, PKC 0, PKC 2, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC-A, PKC-B, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCT, PRKCZ, Pkcea, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, Protooncogene SRC Rous sarcoma, SCA 14, SNF1 sucrose nonfermenting like kinase, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, STE20 like serine/threonine-protein kinase, STE20 related kinase, STK-2, Serine/threonine protein kinase 2, Tyrosine kinase pp60c src, Tyrosine protein kinase PRKCD, Tyrosine protein kinase SRC 1, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), nPKC-delta, nPKC-epsilon, nPKC-theta, p60-Src, p60c-src, pp60c-src, se20 9, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian

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Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (AB146588)
  • Chemical Structure

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Chemical Structure - Staurosporine (DMSO solution), protein kinase inhibitor (AB146588)

2D chemical structure image of ab146588, Staurosporine (DMSO solution), protein kinase inhibitor

주요 정보

CAS 번호

62996-74-1

Purity

>98%

제형

Liquid

form

Molecular weight

466.5 Da

Molecular formula

C<sub>2</sub><sub>8</sub>H<sub>2</sub><sub>6</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

44259

Nature

Synthetic

생화학적 명칭

Staurosporine

생물학적 정보

Potent, cell-permeable, broad spectrum inhibitor of protein kinases. Kinases inhibited include: protein kinase C (IC50 = 3 nM), cAMP-dependent protein kinase (IC50 = 8 nM) and p60v-src (IC50 = 6 nM).

Canonical SMILES

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Isomeric SMILES

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

InChi

InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

InChiKey

HKSZLNNOFSGOKW-FYTWVXJKSA-N

IUPAC Name

(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

1 mM

제품 세부 정보

Check out our range of Protein kinase inhibitor biochemicals here

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PKC isoforms associate with cancer and cardiovascular diseases. PKC epsilon often links with cancer progression particularly breast and lung cancers by interacting with oncogenes that promote tumor growth. PKC beta 2 shows connections with metabolic disorders especially in the context of cardiac dysfunction. Disease links may involve other proteins such as Src kinase which interacts with PKC pathways affecting cell motility and survival in cancerous conditions. Understanding these relationships aids in developing therapeutic strategies targeting PKC-related pathways in disease treatment.
Pathways

Several PKC isoforms engage critical cell signaling pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. In these pathways PKCs modulate various downstream effectors coordinating signals that influence gene expression and cell survival. PKC delta has significant associations with the MAPK cascade while PKC theta interacts closely with PI3K. These interactions are necessary for linking external signals to intracellular responses thereby acting as converging points for signaling pathways impacting multiple cellular functions.

Biological function summary

PKC isoforms regulate cellular functions like proliferation differentiation and apoptosis. These proteins are part of larger signaling complexes participating in dynamic equilibrium states that determine cellular fate. For example PKC epsilon often interacts within complexes modulating oncogenic pathways while PKC beta 2 plays roles in immune response modulation. The distinct expression patterns and interactions of these isoforms enable them to assume specific biological roles in different tissues.

Protein kinase C (PKC) is a family of serine/threonine kinases essential in cellular signaling. The PKC family includes several isoforms such as PKC delta PKC epsilon PKC beta 2 PKC gamma and PKC theta (also known as PRKCQ). These proteins exhibit diverse molecular masses ranging from about 78 kDa to 82 kDa. PKCs are broadly expressed in various tissues and cells particularly in the brain heart and immune cells. PKC isoforms play significant mechanical roles by phosphorylating various substrate proteins influencing various cellular processes.

제품 프로토콜

제품이 사용된 논문 (7)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of general virology 106: PubMed39928567

2025

The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infection.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha K Nguyen,Edward Long,James R Edgar,Andrew E Firth,Hazel Stewart

Aging 15:14172-14191 PubMed38095632

2023

Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Lei,Yong Luo,Dongkun Kang,Fumin Yang,Dongli Meng,Jian-Zhi Wang,Rong Liu,Xiaochuan Wang,Hong-Lian Li

NPJ systems biology and applications 8:46 PubMed36443335

2022

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli.

Applications

Unspecified application

Species

Unspecified reactive species

Dezerae Cox,Angelique R Ormsby,Gavin E Reid,Danny M Hatters

NAR genomics and bioinformatics 4:lqac065 PubMed36110898

2022

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage.

Applications

Unspecified application

Species

Unspecified reactive species

Jianfeng Li,Alison Beiser,Nupur B Dey,Shunichi Takeda,Liton Kumar Saha,Kouji Hirota,L Lynette Parker,Mariah Carter,Martha I Arrieta,Robert W Sobol

Journal of cell science 135: PubMed35274124

2022

Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Paul O'Callaghan,Adam Engberg,Olle Eriksson,Nikos Fatsis-Kavalopoulos,Christina Stelzl,Gonzalo Sanchez,Olof Idevall-Hagren,Johan Kreuger

Cell reports 26:3323-3335.e4 PubMed30893604

2019

DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Oluwatoyin E Akande,Priyadarshan K Damle,Marius Pop,Nicholas E Sherman,Barbara B Szomju,Larisa V Litovchick,Steven R Grossman

PloS one 13:e0206801 PubMed30395621

2018

Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Jeffrey M Lynch,Andrew J Dolman,Chenying Guo,Katie Dolan,Chuanxi Xiang,Samir Reda,Bing Li,Ganesh Prasanna
제품이 사용된 논문 모두 보기

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