JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141063

Taurine, Partial glycine receptor agonist

Be the first to review this product! 리뷰 제출

|

(1 출판물)

MW 125.15 Da, Purity >98%. Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.

대체 명칭 보기

AHR_HUMAN, AP-1, Activator protein 1, Ah receptor, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Class E basic helix-loop-helix protein 76, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Enhancer Binding Protein AP1, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, HGNC:348, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, NF-E2-related factor 2, NF2L2_HUMAN, NR1B1, NR3B1, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 3 group B member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, Oncogene JUN, Proto-oncogene c-jun, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Steroid hormone receptor ERR1, Transcription factor AP-1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, bHLHe76, cJun, erythroid derived 2, estrogen receptor related receptor alpha, hERR1, like 2, nuclear factor erythroid 2 like 2, p39

1 이미지
Chemical Structure - Taurine, Partial glycine receptor agonist (AB141063)
  • Chemical Structure

Lab

Chemical Structure - Taurine, Partial glycine receptor agonist (AB141063)

2D chemical structure image of ab141063, Taurine, Partial glycine receptor agonist

주요 정보

CAS 번호

107-35-7

Purity

>98%

제형

Solid

form

Molecular weight

125.15 Da

Molecular formula

NH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>SO<sub>3</sub>H

PubChem

1123

Nature

Synthetic

Solubility

Soluble in water to 100 mM

생화학적 명칭

Taurine

생물학적 정보

Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.

Canonical SMILES

C(CS(=O)(=O)O)N

InChi

InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)

InChiKey

XOAAWQZATWQOTB-UHFFFAOYSA-N

IUPAC Name

2-aminoethanesulfonic acid

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The c-Jun protein also known as Jun oncogene is a component of the AP-1 transcription factor complex. It has an approximate mass of 39 kDa and is expressed in various tissues across the human body. Aryl hydrocarbon Receptor (AhR) with a mass of around 96 kDa acts as a ligand-activated transcription factor and is also widely expressed especially in the liver. Retinoic Acid Receptor alpha (RARα) weighing about 50 kDa mediates gene expression changes in response to retinoic acid. It mainly appears in tissues with high cell turnover. Estrogen Related Receptor alpha (ERRα) shares structural features with steroid hormone receptors and is notably present in reproductive tissues and metabolic organs. Nrf2 also known as nuclear factor erythroid 2–related factor 2 has approximately 68 kDa in mass and plays a role in regulating oxidative response genes. It expresses broadly particularly in organs facing high oxidative stress.
Biological function summary

C-Jun activates as part of a transcription factor complex such as AP-1 impacting cellular proliferation and differentiation. Aryl hydrocarbon Receptor allows cells to respond to environmental toxins and is part of a complex involving co-chaperones such as Hsp90. Retinoic Acid Receptor alpha modulates gene expression during embryonic development and is part of heterodimer complexes with RXR. Estrogen Related Receptor alpha (ERRα) influences energy metabolism and regulates mitochondrial biogenesis. Nrf2 upregulates antioxidant proteins to maintain redox homeostasis forming a complex with Keap1 in its inactive or repressed state.

Pathways

C-Jun integrates into signaling cascades such as the MAPK and JNK pathways affecting genes related to stress response and apoptosis. The Aryl hydrocarbon Receptor participates in xenobiotic metabolism pathways interacting with proteins like CYP1A1. Retinoic Acid Receptor alpha influences developmental signaling pathways like the Wnt pathway sharing regulation roles with proteins such as beta-catenin. ERRα is involved in energy metabolism pathways intersecting with the PGC-1α family critical for mitochondrial biogenesis. Nrf2 plays an important role in the antioxidant response element (ARE) pathway interacting with proteins like small Maf.

C-Jun is associated with cancer progression and inflammatory diseases interacting with other proteins involved in these conditions like NF-kB. AhR dysfunction links to immune disorders and liver diseases with pathways that share involvement with CYP450 enzymes. Abnormal Retinoic Acid Receptor alpha function is implicated in acute promyelocytic leukemia and developmental disorders interacting with partners such as the fusion protein PML-RARα. Dysregulated ERRα touches on metabolic disorders and cancer with related proteins like PPARγ influencing disease. Nrf2's impaired activity connects to neurodegenerative diseases and chronic obstructive pulmonary disease (COPD) with its pathway involving Keap1.

제품 프로토콜

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 18:4516-4522 PubMed30221665

2018

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoli Niu,Simin Zheng,Hongtao Liu,Siyuan Li
제품이 사용된 논문 모두 보기

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com