MW 125.15 Da, Purity >98%. Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.
대체 명칭 보기
AHR_HUMAN, AP-1, Activator protein 1, Ah receptor, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Class E basic helix-loop-helix protein 76, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Enhancer Binding Protein AP1, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, HGNC:348, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, NF-E2-related factor 2, NF2L2_HUMAN, NR1B1, NR3B1, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 3 group B member 1, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, Oncogene JUN, Proto-oncogene c-jun, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Steroid hormone receptor ERR1, Transcription factor AP-1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, bHLHe76, cJun, erythroid derived 2, estrogen receptor related receptor alpha, hERR1, like 2, nuclear factor erythroid 2 like 2, p39
- Chemical Structure
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Chemical Structure - Taurine, Partial glycine receptor agonist (AB141063)
2D chemical structure image of ab141063, Taurine, Partial glycine receptor agonist
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
C-Jun activates as part of a transcription factor complex such as AP-1 impacting cellular proliferation and differentiation. Aryl hydrocarbon Receptor allows cells to respond to environmental toxins and is part of a complex involving co-chaperones such as Hsp90. Retinoic Acid Receptor alpha modulates gene expression during embryonic development and is part of heterodimer complexes with RXR. Estrogen Related Receptor alpha (ERRα) influences energy metabolism and regulates mitochondrial biogenesis. Nrf2 upregulates antioxidant proteins to maintain redox homeostasis forming a complex with Keap1 in its inactive or repressed state.
Pathways
C-Jun integrates into signaling cascades such as the MAPK and JNK pathways affecting genes related to stress response and apoptosis. The Aryl hydrocarbon Receptor participates in xenobiotic metabolism pathways interacting with proteins like CYP1A1. Retinoic Acid Receptor alpha influences developmental signaling pathways like the Wnt pathway sharing regulation roles with proteins such as beta-catenin. ERRα is involved in energy metabolism pathways intersecting with the PGC-1α family critical for mitochondrial biogenesis. Nrf2 plays an important role in the antioxidant response element (ARE) pathway interacting with proteins like small Maf.
제품이 사용된 논문 (1)
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Molecular medicine reports 18:4516-4522 PubMed30221665
2018
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