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AB142080

Tetrahydrouridine, cytidine deaminase inhibitor

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Tetrahydrouridine (CAS: 18771-50-1)(ab142080) is a potent competitive cytidine deaminase (CDA) inhibitor (IC50= 152 µM) that modulates antiproliferative effects. The molecular weight of Tetrahydrouridine (THU) is 248.23 g/mol.

- Solubility: Water (200 mg/mL) or MeOH (25 mg/mL)
- Multidrug resistance modulator and makes tumor cells more sensitive to radiation therapy making it useful for cancer treatment
- Available in different sizes to fit your experiment needs. Larger volume format available upon request.
1 이미지
Chemical Structure - Tetrahydrouridine, cytidine deaminase inhibitor (AB142080)
  • Chemical Structure

Lab

Chemical Structure - Tetrahydrouridine, cytidine deaminase inhibitor (AB142080)

2D chemical structure image of ab142080, Tetrahydrouridine, cytidine deaminase inhibitor

주요 정보

CAS 번호

18771-50-1

Purity

>80%

Molecular weight

248.23 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>6</sub>

PubChem

270480

Nature

Synthetic

Solubility

Soluble in water to 100 mM

생화학적 명칭

2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-

생물학적 정보

Competitive cytidine deaminase inhibitor (IC50= 152 μM). Modulates antiproliferative effects. Orally active.

Canonical SMILES

C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O

InChi

InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)

InChiKey

UCKYOOZPSJFJIZ-UHFFFAOYSA-N

IUPAC Name

1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

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보완 제품

Sample Prep & Detection Kits

AB102921

Streptavidin Conjugation Kit - Lightning-Link®

Conjugation - Streptavidin Conjugation Kit - Lightning-Link® (AB102921)

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Biochemicals

AB120649

SC-560, COX-1 inhibitor

Chemical Structure - SC-560, COX-1 inhibitor (AB120649)

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Biochemicals

AB141003

MG-132, proteasome inhibitor

Immunocytochemistry/ Immunofluorescence - MG-132, proteasome inhibitor (AB141003)

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Assay Kits

AB211091

MTT Assay Kit (Cell Proliferation)

Functional Studies - MTT Assay Kit (Cell Proliferation) (AB211091)

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제품 세부 정보

Tetrahydrouridine (THU) is a synthetic pyrimidine nucleoside analogue and is a well characterized and potent inhibitor of cytidine deaminase (CDA). Cytidine deaminase is a key enzyme involved in the pyrimidine salvage pathway.

Use our Tetrahydrouridine, cytidine deaminase inhibitor (ab142080) for applications related to nucleotide metabolism and cancer-programmed cell death.

This product is manufactured by BioVision, an Abcam company and was previously called 1671 Tetrahydrouridine. 1671-25 is the same size as the 25 mg size of ab142080.
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:4451 PubMed40360497

2025

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.

Applications

Unspecified application

Species

Unspecified reactive species

Julie A I Thoms,Feng Yan,Henry R Hampton,Sarah Davidson,Swapna Joshi,Jesslyn Saw,Chowdhury H Sarowar,Xin Ying Lim,Andrea C Nunez,Purvi M Kakadia,Golam Sarower Bhuyan,Xiaoheng Zou,Mary Nguyen,Elaheh S Ghodousi,Forrest C Koch,Fatemeh Vafaee,I Richard Thompson,Mohammad M Karimi,Russell Pickford,Mark J Raftery,Sally Hough,Griselda Buckland,Michelle Bailey,Yuvaraj Ghodke,Noorul Absar,Lachlin Vaughan,Leonardo Pasalic,Chun Y Fong,Melita Kenealy,Devendra K Hiwase,Rohanna I Stoddart,Soma Mohammed,Linda Lee,Freda H Passam,Stephen R Larsen,Kevin J Spring,Kristen K Skarratt,Patricia Rebeiro,Peter Presgrave,William S Stevenson,Silvia Ling,Campbell Tiley,Stephen J Fuller,Fernando Roncolato,Anoop K Enjeti,Dirk Hoenemann,Charlotte Lemech,Christopher J Jolly,Stefan K Bohlander,David J Curtis,Jason W H Wong,Ashwin Unnikrishnan,Mark Hertzberg,Jake Olivier,Mark N Polizzotto,John E Pimanda
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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