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AB120580

Thioridazine hydrochloride, Dopamine receptor antagonist

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MW 407 Da, Purity >99%. Dopamine receptor antagonist (Ki values are 16 (D2), 10 (D1), 7.8 (D3), and 31 (D4) nM). Also inhibits CYP2D6 (IC50 = 2.7 μM). Antipsychotic. Displays antituberculosis/ drug-resistant tuberculosis properties.

대체 명칭 보기

2700049B16Rik, 3110031N04Rik, A830040C14Rik, ACEE, ACES_HUMAN, ACLS, AI838772, AIS, ANDR_HUMAN, AP-1, APOPAIN, AR, AR8, ARACHE, ARO, ARO1, AW493413, Acetylcholinesterase, Activator protein 1, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Antigen NY-CO-13, Apoptosis related acetylcholinesterase, Apoptotic protease Mch-3, Aromatase, Atherosclerosis, susceptibility to, included, BAZ2B_HUMAN, BCC7, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, BXR, Bromodomain adjacent to zinc finger domain 2B, Bromodomain adjacent to zinc finger domain protein 2B, CAPC, CASP3_HUMAN, CASP7_HUMAN, CC3, CMH-1, CP19A_HUMAN, CPP-32, CPP32B, CPV1, CYAR, CYP19, CYPXIX, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Casp3a, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase 7, Caspase 7 apoptosis related cysteine peptidase, Caspase-3, Caspase-3 subunit p12, Caspase-7 subunit p11, Cellular tumor antigen p53, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cyp19a1, Cysteine protease CPP32, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), Cytokeratin-associated protein in cancer, Cytosolic NADP-isocitrate dehydrogenase, DHTR, DKFZp434H071, DKFZp686N23123, DKFZp762I0516, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Drosophila slowpoke like, EC 3.4.22.56, ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Eag-related protein 1, Enhancer Binding Protein AP1, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FLJ11090, FLJ45644, FLJ92943, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, H-ERG, HDL cholesterol, augmented response of, to hormone replacement, included, HEL-216, HEL-S-26, HSMPP8, HUMARA, HYSP1, Hbeta1, Hbeta2, Hbeta3, Hbeta4, ICDH, ICE-LAP3, ICE-like apoptotic protease 3, ICE3, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, IMD42, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNH2_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, KD, Kennedy disease (KD), Kv11.1, LFS1, LICE, LICE2, LQT 2, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, M-phase phosphoprotein 8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, MCH3, MGC104252, MGC104309, MGC112732, MGC129539, MGC22431, MGC57945, MPHOSPH8, MPP8_HUMAN, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, Microsomal monooxygenase, Mutant tumor protein 53, Myocardial infarction, susceptibility to, included, N-ACHE, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NR1B1, NR1F3, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000162543, OTTHUMP00000162897, OTTHUMP00000162898, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, OTTHUMP00000198350, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Oncogene JUN, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Oxalosuccinate decarboxylase, P 450AROM, P53_HUMAN, PAP A, PAPB, PAR, PAR q, PARP cleavage protease, PICD, PPD IV, PRR, Phosphoprotein p53, Potassium channel HERG, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, Procaspase3, Protein Yama, Proto-oncogene c-jun, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-related orphan receptor C, RARA_HUMAN, RARalpha1, RNESTROR, RORG_HUMAN, RP11-523H24.1, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoid-related orphan receptor-gamma, Rorc, SAKCA, SBMA, SCA-1, SCAN1, SLO, SMAX1, SQT1, SREBP cleavage activity 1, SXR, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TRP53, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Tp53, Transcription factor AP-1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Twa3, Two hybrid-associated protein 3 with RanBPM, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, WALp4, YT, YT blood group, Yama, Yama protein, Zinc finger protein GLI 3, androgen receptor splice variant 4b, bA350O14.10, cJun, cytokeratin-associated protein, eag homolog, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERG-1, hERR1, hSlo, hWALp4, hslo beta, mldy, p39, p53 tumor suppressor, pregnane X nuclear receptor variant 2, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4, tumor antigen p55

1 이미지
Chemical Structure - Thioridazine hydrochloride, Dopamine receptor antagonist (AB120580)
  • Chemical Structure

Lab

Chemical Structure - Thioridazine hydrochloride, Dopamine receptor antagonist (AB120580)

2D chemical structure image of ab120580, Thioridazine hydrochloride, Dopamine receptor antagonist

주요 정보

CAS 번호

130-61-0

Purity

>99%

제형

Solid

form

Molecular weight

407 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>7</sub>ClN<sub>2</sub>S<sub>2</sub>

PubChem

66062

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

생화학적 명칭

Thioridazine hydrochloride

생물학적 정보

Dopamine receptor antagonist (Ki values are 16 (D2), 10 (D1), 7.8 (D3), and 31 (D4) nM). Also inhibits CYP2D6 (IC50 = 2.7 μM). Antipsychotic. Displays antituberculosis/ drug-resistant tuberculosis properties.

Canonical SMILES

CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl

InChi

InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

InChiKey

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

IUPAC Name

10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

제품 프로토콜

Product promise

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