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AB230366

Ticagrelor, P2Y12 receptor antagonist

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MW 522.6 Da, Purity >98%. Reversible antagonist of the platelet purinergic P2Y12 receptor, the main receptor responsible for ADP-induced platelet aggregation. Changes the conformation of the P2Y12 receptor, resulting in reversible, concentration dependent inhibition of the receptor.

대체 명칭 보기

ADP-glucose receptor, ADPG-R, BDPLT8, G protein coupled receptor SP1999, Gi coupled ADP receptor HORK3, HORK 3, P2RY 12, P2T(AC), P2Y purinoceptor 12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, P2Y12_HUMAN, Platelet ADP receptor, Purinergic receptor P2RY12, Purinergic receptor P2Y G protein coupled 12, Purinergic receptor P2Y12, Putative G protein coupled receptor, SP 1999

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Chemical Structure - Ticagrelor, P2Y12 receptor antagonist (AB230366)
  • Chemical Structure

Lab

Chemical Structure - Ticagrelor, P2Y12 receptor antagonist (AB230366)

2D chemical structure image of ab230366, Ticagrelor, P2Y12receptor antagonist

주요 정보

CAS 번호

274693-27-5

Purity

>98%

제형

Solid

form

Molecular weight

522.6 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>8</sub>F<sub>2</sub>N<sub>6</sub>O<sub>4</sub>S

PubChem

9871419

Nature

Synthetic

Solubility

Ticagrelor has a solubility of approximately 0.15 mg/ml in a 1:5 solution of DMF:PBS (pH 7.2). We do not recommend storing the aqueous solution for more than one day.

생화학적 명칭

Ticagrelor

생물학적 정보

Reversible antagonist of the platelet purinergic P2Y12 receptor, the main receptor responsible for ADP-induced platelet aggregation. Changes the conformation of the P2Y12 receptor, resulting in reversible, concentration dependent inhibition of the receptor.

Canonical SMILES

CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F

Isomeric SMILES

CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F

InChi

InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1

InChiKey

OEKWJQXRCDYSHL-FNOIDJSQSA-N

IUPAC Name

(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

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보완 제품

Primary Antibodies

AB272329

APC Anti-PD-L1 antibody [10F.9G2]

Flow Cytometry - APC Anti-PD-L1 antibody [10F.9G2] (AB272329)

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Biochemicals

AB120221

(R,S)-CHPG sodium salt, mGlu5 agonist; water soluble

Chemical Structure - (R,S)-CHPG sodium salt, mGlu5 agonist; water soluble (AB120221)

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Biochemicals

AB120432

Tertiapin Q, blocker of inward-rectifier r K+ channels

Functional Studies (Act) - Tertiapin Q, blocker of inward-rectifier r K+ channels (AB120432)

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Biochemicals

AB275490

Calcein Blue AM acetate

Chemical Structure - Calcein Blue AM acetate (AB275490)

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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Toxic, refer to SDS for further information.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

P2Y12 also referred to as the P2Y12 receptor is a G-protein coupled receptor with an approximate mass of 39.6 kDa. It plays a distinct role in platelet aggregation through ADP binding which activates intracellular signaling pathways that result in platelet activation. One finds P2Y12 expressed mainly in platelets and the brain. It is an important target of various antiplatelet drugs which highlights its critical role in physiological frameworks involving thrombosis.
Biological function summary

The P2Y12 receptor is an important component of the platelet activation pathway. When activated it contributes to the amplification of platelet responses to injury. P2Y12 does not function in isolation; it forms part of larger multi-protein complexes essential for thrombus formation. This aggregation process requires synchronized activation of several platelet receptors emphasizing the P2Y12 receptor's critical role in maintaining hemostasis through cellular signaling.

Pathways

The P2Y12 receptor is integral to the thrombin and ADP signaling pathways functioning in tandem with other proteins such as the P2Y1 and CXCR4 receptors to execute cellular responses. These pathways facilitate platelet shape change secretion and aggregation therefore solidifying their place within the broader scope of hemostatic responses. Coordination with such protein partners ensures efficient propagation of signals necessary for rapid platelet activation and clot formation.

P2Y12 is closely linked to cardiovascular diseases particularly thrombosis and myocardial infarction. Its involvement in excessive platelet aggregation makes it a significant target for therapeutic agents like the P2Y12 receptor blockers. The receptor also interacts with proteins like glycoprotein IIb/IIIa in the clotting process providing potential pathways for therapeutic intervention. Dysregulation of P2Y12 function presents a risk for unwarranted thrombotic events highlighting the importance of P2Y12 antagonists such as ticagrelor in clinical settings to manage such conditions effectively.
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제품 프로토콜

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Product promise

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