U-83836E, Lazaroid antioxidant

주요 정보

CAS 번호

133681-84-2

Purity

>98%

Molecular weight

593.6 Da

Molecular formula

C₃₀H₄₆Cl₂N₆O₂

PubChem

107656

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in ethanol to 75 mM

생화학적 명칭

2-Methyl aminochroman

생물학적 정보

Lazaroid antioxidant, a steroid compound that inhibits lipid peroxidation. Inhibits cell proliferation (IC₅₀ = 6.30 mM). Potent free radical scavenger. Significantly protects against LPS induced lethality. Reduces secondary brain injury in a rabbit model of cryogenic trauma. Active in vivo and in vitro.

Canonical SMILES

CC1=C(C2=C(CCC(O2)(C)CN3CCN(CC3)C4=NC(=NC(=C4)N5CCCC5)N6CCCC6)C(=C1O)C)C.Cl.Cl

InChi

InChI=1S/C30H44N6O2.2ClH/c1-21-22(2)28-24(23(3)27(21)37)9-10-30(4,38-28)20-33-15-17-35(18-16-33)26-19-25(34-11-5-6-12-34)31-29(32-26)36-13-7-8-14-36;;/h19,37H,5-18,20H2,1-4H3;2*1H

InChiKey

KJGXSMZHYBXPIS-UHFFFAOYSA-N

IUPAC Name

2-[[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]methyl]-2,5,7,8-tetramethyl-3,4-dihydrochromen-6-ol;dihydrochloride