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AB120140

Verapamil hydrochloride, L-type Ca2+ channel blocker

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(4 제품이 사용된 논문 )

MW 491.1 Da, Purity >99%. L-type Ca2+ channel blocker. Antiarrhythmic in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

대체 명칭 보기

1,8-cineole 2-exo-monooxygenase, ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, ACLS, AI838772, AIS, ANDR_HUMAN, AP-1, AR, AR8, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, AW493413, Activator protein 1, Albendazole monooxygenase, Albendazole sulfoxidase, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Atherosclerosis, susceptibility to, included, BRIC2, BXR, Bile salt export pump, Bsep, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Eag-related protein 1, Enhancer Binding Protein AP1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FLJ11090, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, Glucocorticoid inducible P450, H-ERG, HDL cholesterol, augmented response of, to hormone replacement, included, HLP, HUMARA, HYSP1, IMD42, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, KCNH2_HUMAN, KD, Kennedy disease (KD), Kv11.1, LQT 2, MGC104252, MGC112732, MGC126680, MGC129539, Myocardial infarction, susceptibility to, included, NF 25, NR1F3, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nifedipine oxidase, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Oncogene JUN, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PAP A, PAPB, PAR, PAR q, PFIC 2, PGY4, PPD IV, PRR, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, Proto-oncogene c-jun, Quinine 3-monooxygenase, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RNESTROR, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, SQT1, SXR, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Testicular Feminization (TFM), Transcription factor AP-1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, cJun, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, eag homolog, estrogen receptor related receptor alpha, hERG-1, hERR1, p39, pregnane X nuclear receptor variant 2, progressive familial intrahepatic cholestasis 2

1 이미지
Chemical Structure - Verapamil hydrochloride, L-type Ca2+ channel blocker (AB120140)
  • Chemical Structure

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Chemical Structure - Verapamil hydrochloride, L-type Ca2+ channel blocker (AB120140)

2D chemical structure image of ab120140, Verapamil hydrochloride, L-type Ca2+ channel blocker

주요 정보

CAS 번호

152-11-4

Purity

>99%

제형

Solid

form

Molecular weight

491.1 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>9</sub>ClN<sub>2</sub>O<sub>4</sub>

PubChem

62969

Nature

Synthetic

생화학적 명칭

Verapamil hydrochloride

생물학적 정보

L-type Ca2+ channel blocker. Antiarrhythmic in vivo. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical SMILES

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

InChi

InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChiKey

DOQPXTMNIUCOSY-UHFFFAOYSA-N

IUPAC Name

2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C-Jun also known as a part of the activator protein 1 (AP-1) complex is a transcription factor with a molecular weight of around 39 kDa. It is widely expressed in various tissues playing a critical role in regulating gene expression. The Estrogen Receptor (ER) a nuclear receptor with approximately 66 kDa mass is vital for mediating estrogen's effects primarily in reproductive tissues but also in bone and brain. Gli3 part of the Gli family operates as a transcription factor involved in developmental processes and displays a molecular weight of roughly 190 kDa. Cytochrome P450 3A4 (CYP3A4) serves as an important enzyme in drug metabolism abundantly found in the liver. TDP1 a DNA repair enzyme weighing about 75 kDa functions mainly in the nucleus. The Androgen Receptor (AR) another nuclear receptor around 110 kDa is essential in the signaling of male hormones. PXR or Pregnane X Receptor directs the expression of enzymes involved in xenobiotic metabolism. Estrogen Related Receptor alpha (ERRα) a nuclear receptor not activated by estrogen holds significance in energy metabolism. ROR gamma assigned to the nuclear hormonous receptor family influences immune response regulation. H-ERG encodes a potassium channel important in cardiac electrical activity. ABCB11 or Bile Salt Export Pump (BSEP) primarily executes bile acid transport in the liver.
Biological function summary

C-Jun impacts cell proliferation apoptosis and differentiation often forming heterodimers with c-Fos in the AP-1 complex. ER regulates genes linked to cell proliferation and differentiation important for reproductive system function. Gli3 partakes in the Hedgehog signaling pathway providing key directives during limb development and neural patterning. CYP3A4 influences steroid metabolism and detoxification of chemicals. TDP1 repairs DNA targeting topoisomerase I-induced DNA breaks. AR oversees the regulation of genes in male traits and reproductive activity. PXR orchestrates the response to endogenous and exogenous substances modulating the expression of detoxifying enzymes. ERRα contributes to mitochondrial biogenesis and energy regulation. ROR gamma affects thymocyte development and inflammatory processes. H-ERG regulates cardiac rhythmicity. BSEP transports bile acids ensuring proper liver function.

Pathways

C-Jun integrates into the MAPK signaling pathway functioning alongside proteins like JNK to affect cell fate. ER participates in the estrogen signaling pathway interacting with co-regulators and other receptors such as ERRα to modulate transcription. Gli3 connects the Hedgehog pathway with proteins like Smoothened and Patched influencing tissue patterning. CYP3A4 fits within the xenobiotic metabolism pathway working with PXR and AR to detoxify compounds and metabolic regulation. TDP1 engages in DNA repair pathways collaborating with PARP for efficient genomic maintenance. AR interacts with steroid biosynthesis and signaling pathways closely linked with the ER in hormonal regulation. PXR associates with the pregnane X receptor pathway vital for xenobiotic substance metabolism. ERRα interfaces with the PGC-1α pathway influencing genes involved in oxidative metabolism. ROR gamma participates in the circadian rhythm and immune response pathways with connections to ER. H-ERG ties to cardiac-related pathways including those for calcium signaling. BSEP integrates into the bile acid metabolism pathway interacting with hepatic transport proteins.

Abnormalities in c-Jun expression relate to cancers such as breast and liver cancer showing links with other AP-1 components like c-Fos. ER's involvement in breast cancer is well-documented connecting with other nuclear receptors like AR. Gli3 mutations result in disorders like Pallister-Hall syndrome and Greig cephalopolysyndactyly syndrome implicating interactions with components of the Hedgehog pathway. CYP3A4 variability affects drug responses influencing conditions like liver disease with PXR contributing to its regulatory control. Dysfunction in TDP1 associates with neurodegenerative diseases such as spinocerebellar ataxia where interactions with DNA repair proteins are important. AR mutations link to androgen insensitivity syndrome and prostate cancer related to ER in hormonal signaling. PXR variations affect drug metabolism contributing to liver disorders. ERRα dysregulation impacts metabolic syndromes like diabetes with connections to mitochondrial function. ROR gamma associates with autoimmune diseases with immune pathway ties. H-ERG mutations often result in long QT syndrome affecting calcium and potassium channel regulation. BSEP deficiencies lead to cholestatic liver disease requiring efficient hepatic bile acid transport.

제품 프로토콜

제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular oncology 18:386-414 PubMed37842807

2023

Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer and overcoming drug resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Yao-Yu Hsieh,Jia-Ling Du,Pei-Ming Yang

Nutrition & metabolism 18:74 PubMed34274001

2021

Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic β-cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Šrámek,Vlasta Němcová,Jan Kovář

SLAS technology 22:536-546 PubMed28430559

2017

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Kobuszewska,Ewelina Tomecka,Kamil Zukowski,Elzbieta Jastrzebska,Michal Chudy,Artur Dybko,Philippe Renaud,Zbigniew Brzozka

American journal of physiology. Heart and circulat 300:H2016-26 PubMed21421826

2011

Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.

Applications

Unspecified application

Species

Unspecified reactive species

Neerupma Silswal,Nikhil K Parelkar,Michael J Wacker,Marco Brotto,Jon Andresen
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