Verapamil hydrochloride, L-type Ca2+ channel blocker
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(4 제품이 사용된 논문 )
MW 491.1 Da, Purity >99%. L-type Ca2+ channel blocker. Antiarrhythmic in vivo. Soluble in 1 ml water to give specified mM/ml concentration.
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1,8-cineole 2-exo-monooxygenase, ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, ACLS, AI838772, AIS, ANDR_HUMAN, AP-1, AR, AR8, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, AW493413, Activator protein 1, Albendazole monooxygenase, Albendazole sulfoxidase, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Atherosclerosis, susceptibility to, included, BRIC2, BXR, Bile salt export pump, Bsep, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Eag-related protein 1, Enhancer Binding Protein AP1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FLJ11090, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, Glucocorticoid inducible P450, H-ERG, HDL cholesterol, augmented response of, to hormone replacement, included, HLP, HUMARA, HYSP1, IMD42, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, KCNH2_HUMAN, KD, Kennedy disease (KD), Kv11.1, LQT 2, MGC104252, MGC112732, MGC126680, MGC129539, Myocardial infarction, susceptibility to, included, NF 25, NR1F3, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nifedipine oxidase, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Oncogene JUN, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PAP A, PAPB, PAR, PAR q, PFIC 2, PGY4, PPD IV, PRR, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, Proto-oncogene c-jun, Quinine 3-monooxygenase, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RNESTROR, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, SQT1, SXR, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Testicular Feminization (TFM), Transcription factor AP-1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, cJun, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, eag homolog, estrogen receptor related receptor alpha, hERG-1, hERR1, p39, pregnane X nuclear receptor variant 2, progressive familial intrahepatic cholestasis 2
- Chemical Structure
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Chemical Structure - Verapamil hydrochloride, L-type Ca2+ channel blocker (AB120140)
2D chemical structure image of ab120140, Verapamil hydrochloride, L-type Ca2+ channel blocker
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취급 방법
Need more advice on solubility, usage and handling? Please visit our our product support page for more details.
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
C-Jun impacts cell proliferation apoptosis and differentiation often forming heterodimers with c-Fos in the AP-1 complex. ER regulates genes linked to cell proliferation and differentiation important for reproductive system function. Gli3 partakes in the Hedgehog signaling pathway providing key directives during limb development and neural patterning. CYP3A4 influences steroid metabolism and detoxification of chemicals. TDP1 repairs DNA targeting topoisomerase I-induced DNA breaks. AR oversees the regulation of genes in male traits and reproductive activity. PXR orchestrates the response to endogenous and exogenous substances modulating the expression of detoxifying enzymes. ERRα contributes to mitochondrial biogenesis and energy regulation. ROR gamma affects thymocyte development and inflammatory processes. H-ERG regulates cardiac rhythmicity. BSEP transports bile acids ensuring proper liver function.
Pathways
C-Jun integrates into the MAPK signaling pathway functioning alongside proteins like JNK to affect cell fate. ER participates in the estrogen signaling pathway interacting with co-regulators and other receptors such as ERRα to modulate transcription. Gli3 connects the Hedgehog pathway with proteins like Smoothened and Patched influencing tissue patterning. CYP3A4 fits within the xenobiotic metabolism pathway working with PXR and AR to detoxify compounds and metabolic regulation. TDP1 engages in DNA repair pathways collaborating with PARP for efficient genomic maintenance. AR interacts with steroid biosynthesis and signaling pathways closely linked with the ER in hormonal regulation. PXR associates with the pregnane X receptor pathway vital for xenobiotic substance metabolism. ERRα interfaces with the PGC-1α pathway influencing genes involved in oxidative metabolism. ROR gamma participates in the circadian rhythm and immune response pathways with connections to ER. H-ERG ties to cardiac-related pathways including those for calcium signaling. BSEP integrates into the bile acid metabolism pathway interacting with hepatic transport proteins.
제품이 사용된 논문 (4)
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Molecular oncology 18:386-414 PubMed37842807
2023
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Nutrition & metabolism 18:74 PubMed34274001
2021
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SLAS technology 22:536-546 PubMed28430559
2017
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American journal of physiology. Heart and circulat 300:H2016-26 PubMed21421826
2011
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