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AB141382

Z-IETD-FMK, Caspase-8 inhibitor

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(8 제품이 사용된 논문 )

MW 654.7 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)
  • FuncS

Unknown

Functional Studies - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)

ab13847 staining active caspase 3 in SKNSH cells treated with Z-IETD-FMK (ab141382), by ICC/IF. Decrease in active caspase 3 expression correlates with increased concentration of Z-IETD-FMK, as described in literature.
The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141382 (Z-IETD-FMK) in DMSO. After this incupation 10 µM of camptothecin (ab120115) was added to all samples and the cells were incubated for further 24 hours. The samples were then fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13847 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DA

Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)
  • Chemical Structure

Lab

Chemical Structure - Z-IETD-FMK, Caspase-8 inhibitor (AB141382)

2D chemical structure image of ab141382, Z-IETD-FMK, Caspase-8 inhibitor

주요 정보

CAS 번호

210344-98-2

Purity

>99%

제형

Lyophilized

form

Molecular weight

654.7 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>4</sub><sub>3</sub>FN<sub>4</sub>O<sub>1</sub><sub>1</sub>

PubChem

44135212

Nature

Synthetic

생화학적 명칭

Caspase-8 inhibitor

Canonical SMILES

CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChi

InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)

InChiKey

PHLCQASLWHYEMX-UHFFFAOYSA-N

IUPAC Name

methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

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보완 제품

Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

  • 4
  • 12
Sample Prep & Detection Kits

AB65320

Mitochondria/Cytosol Fractionation Kit

  • 0
  • 0
Biochemicals

AB142116

Chloroquine diphosphate, apoptosis and autophagy inhibitor

Immunocytochemistry - Chloroquine diphosphate, apoptosis and autophagy inhibitor (AB142116)

  • 0
  • 0
Primary Antibodies

AB227713

Anti-CAMTA1 antibody

Western blot - Anti-CAMTA1 antibody (AB227713)

  • 0
  • 0
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제품 세부 정보

This product is manufactured by BioVision, an Abcam company and was previously called 1148 IETD-FMK, Z-,. 1148-5 is the same size as the 5 mg size of ab141382.
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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제품 프로토콜

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제품이 사용된 논문 (8)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Translational andrology and urology 13:1405-1415 PubMed39280678

2024

External pressure induces the dysfunction of spermatogonia via triggering the intrinsic pathway of apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Liu,Qihao Sun,Kun Du,Houtao Long,Daofeng Zhang,Junhao Zheng,Yong Zhao,Haiyang Zhang

Pharmaceutical biology 62:53-61 PubMed38108311

2023

Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury.

Applications

Unspecified application

Species

Unspecified reactive species

Aiwen Feng,Shaosheng Su,Cheng Li,Yutian Kang,Jiasheng Qiu,Jun Zhou

Scientific reports 12:12317 PubMed35853963

2022

Direct cleavage of caspase-8 by herpes simplex virus 1 tegument protein US11.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Musarra-Pizzo,Rosamaria Pennisi,Daniele Lombardo,Tania Velletri,Maria Teresa Sciortino

Frontiers in microbiology 12:654709 PubMed34484133

2021

SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiping Yang,Qiong Zhao,Jingjing Rao,Feng Zeng,Shengren Yuan,Manshan Ji,Xiaoguang Sun,Jian Li,Jing Yang,Jingwen Cui,Zhixiong Jin,Long Liu,Zhixin Liu

Redox biology 30:101415 PubMed31901590

2020

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Pingjun Zhu,Ruibing Li,Jun Ren,Hao Zhou

World journal of gastrointestinal oncology 11:377-392 PubMed31139308

2019

Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Yang,Jian-Xin Liu,Hai-Xia Shang,Shan Lin,Jin-Yan Zhao,Jiu-Mao Lin

Scientific reports 7:977 PubMed28428545

2017

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Liu,Yan Yuan,Mengfei Long,Tongwang Luo,Jianchun Bian,Xuezhong Liu,Jianhong Gu,Hui Zou,Ruilong Song,Yi Wang,Lin Wang,Zongping Liu

Prostate cancer and prostatic diseases 19:358-366 PubMed27431500

2016

Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Y Zhao,J J Lv,J Chen,X B Jin,M W Wang,Z H Su,L Y Wang,H Y Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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