ZM 336372, c-Raf inhibitor

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MW 389.4 Da, Purity >98%. Potent, cell-permeable and selective c-Raf inhibitor (IC₅₀ = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.

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1,8-cineole 2-exo-monooxygenase, 94 kDa B raf protein, AI838772, AKT, AKT1_HUMAN, AW493413, Albendazole monooxygenase, Albendazole sulfoxidase, Antigen NY-CO-13, B Raf proto oncogene serine threonine protein kinase, B Raf proto oncogene, serine/threonine kinase, B raf 1, B-Raf proto-oncogene serine/threonine-protein kinase (p94), BCC7, BRAF_HUMAN, C AKT, C-Raf proto-oncogene, serine/threonine kinase, C-raf, CARD 3, CARD carrying kinase, CARD containing ICE associated kinase, CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase, CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARDIAK, CLARP kinase, CMD1NN, CP33, CP34, CP3A4_HUMAN, CSAID Binding Protein 1, CSAID-binding protein, CSBP, CSBP 1, CSBP 2, CSPB1, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cellular tumor antigen p53, Craf 1 transforming gene, Csaids binding protein, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.11.1, EXIP, FLJ11090, FLJ92943, FLJ95109, GIG 30, Glucocorticoid inducible P450, Growth inhibiting gene 30, HLP, Human p38Beta MAP kinase mRNA complete cds, IMD22, LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LFS1, LSK, Lck p56, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MAP kinase 11, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAP kinase p38 beta, MAPK 11, MAPK 14, MAX-interacting protein 2, MGC104252, MGC112732, MGC126680, MGC126806, MGC138284, MGC99656, MK11_HUMAN, MK14_HUMAN, Membrane associated protein tyrosine kinase, Mitogen activated protein kinase p38 2, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, Mitogen-activated protein kinase p38 beta, Murine sarcoma 3611 oncogene 1, Murine sarcoma viral (v-raf) oncogene homolog B1, Murine sarcoma viral v raf oncogene homolog B1, Mutant tumor protein 53, Mxi 2, NF 25, NS5, NS7, Nifedipine oxidase, OTTHUMP00000160218, OTTHUMP00000207813, OTTHUMP00000209389, Oncogen BRAF, Oncogene MIL, Oncogene RAF1, Oncogene lck, P38, P38BETA2, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, P53_HUMAN, PKB, PKB-ALPHA, PRKBA, PRKM11, PRKM14, PRKM15, Phosphoprotein p53, Protein Kinase B Alpha, Protein YT16, Protein kinase B, Protein kinase mitogen activated 11, Protein kinase raf 1, Proto oncogene tyrosine protein kinase LCK, Proto-oncogene B-Raf, Proto-oncogene Lck, Proto-oncogene c-Akt, Proto-oncogene c-RAF, Proto-oncogene c-Rmil, Quinine 3-monooxygenase, RAC, RAC Serine/Threonine Protein Kinase, RAC-ALPHA, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase, RAF, RAF proto-oncogene serine/threonine-protein kinase, RAF1_HUMAN, RAFB 1, RICK, RIP-like-interacting CLARP kinase, RIPK2_HUMAN, RK, RMIL, RP24-311F12.2, Rac protein kinase alpha, Raf 1 proto oncogene serine/threonine kinase, Raf proto oncogene serine threonine protein kinase, Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase, Receptor interacting serine threonine kinase 2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, SAPK2, SAPK2A, SAPK2B, SCAN1, Sarcoma 3611 oncogene, Serine/threonine-protein kinase B-raf, Similar to murine leukemia viral (V-raf-1) oncogene homolog 1, Stress activated protein kinase 2b, Stress-activated protein kinase 2, Stress-activated protein kinase 2a, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, TNFRSF, TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, TRP53, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosine-protein kinase Lck, Tyrosine-protein kinase RIPK2, Tyrosyl-DNA phosphodiesterase 1, UNQ277/PRO314/PRO34092, V-AKT murine thymoma viral oncogene homolog 1, YT 16, cRmil, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, kinase Raf1, oncogene BRAF1, p38 ALPHA, p38 MAP kinase, p38 MAPK, p38 mitogen activated protein kinase, p38-2, p38B, p38Beta, p38alpha Exip, p53 tumor suppressor, p56(LSTRA) protein tyrosine kinase, p56-LCK, p94, pp58 lck, tumor antigen p55, v raf 1 murine leukemia viral oncogene homolog 1, v raf murine sarcoma viral oncogene homolog B, v-Raf murine sarcoma viral oncogene homolog B1, v-raf murine sarcoma viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1, vRaf1 murine leukemia viral oncogene homologue 1