AIBZIP overexpression 293T lysate (whole cell)

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AIBZIP also known as Activating Immune Response Protein BZIP is a transcription factor involved in regulating gene expression. This protein with a molecular mass of approximately 45 kDa plays an important role in cellular functioning. Researchers have observed AIBZIP expression mainly in the immune cells including B and T lymphocytes. It regulates genes involved in immune responses by binding to DNA at specific sites assisting in the control of gene transcription.

Biological function summary

AIBZIP is a regulator of immune cell communication and response. AIBZIP forms a complex with other bZIP family proteins enabling it to influence a wide range of cellular processes. AIBZIP modulates expression of cytokines and other immunologically relevant genes. Proper function of AIBZIP ensures cells can effectively respond to pathogens and maintain immune homeostasis.

Pathways

AIBZIP acts in the NF-kB signaling pathway and JAK-STAT pathway both important for immune response and inflammation regulation. It interacts with proteins like RelA in the NF-kB pathway which modulates inflammatory responses and STAT3 in the JAK-STAT pathway that affects cellular growth and differentiation. Through these pathways AIBZIP influences many immune system functions and contributes to the regulation of immune cell activity.

AIBZIP impacts conditions like autoimmune disorders and certain cancers. Dysregulation of AIBZIP can lead to improper immune responses contributing to autoimmune diseases such as lupus. It also links to cancerous processes by affecting the immune system’s ability to fight tumor cells interacting with proteins like p53 that are important for cell cycle regulation. Understanding these interactions can help in developing targeted therapies for such diseases.