PTPRS KO cell lysate available now. KO validated. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon5 and 1 bp insertion in exon5.
대체 명칭 보기
PTPRS, R-PTP-sigma, R-PTP-S, Receptor-type tyrosine-protein phosphatase S, Receptor-type tyrosine-protein phosphatase sigma
- Sanger seq
Unknown
Sanger Sequencing - Human PTPRS knockout HeLa cell lysate (AB263321)
Allele-1 : 1 bp deletion in exon5
- Sanger seq
Unknown
Sanger Sequencing - Human PTPRS knockout HeLa cell lysate (AB263321)
Allele-2 : 1 bp insertion in exon5
보완 제품
제품 세부 정보
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.
제품 구성
특성 및 보관 정보
유전자명
유전자 편집 종류
유전자 편집 방식
Knockout 검증
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Protein Tyrosine Phosphatase Receptor Type S affects multiple cellular processes. It is not part of a large protein complex but interacts with cell adhesion molecules and other proteins involved in cell growth and differentiation. PTPRS contributes to neural development and repair by influencing axonal growth and guidance. It regulates synaptic architecture by modulating signaling pathways that affect neural plasticity and regeneration.
Pathways
PTPRS is involved in neural-related signaling cascades modulating cellular responses. One notable pathway where PTPRS plays a significant role is the Src pathway which regulates processes related to growth and differentiation. PTPRS interacts with proteins like Src kinase family members impacting their activity through dephosphorylation. This modulation of kinase activity directly influences cellular outcomes such as proliferation and cell motility.
품질 관리
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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